Module 2 Flashcards
Non-targeted analytes which may impact the ability to detect, identify, or quantitate a targeted analyte:
Interferences
The lowest concentration of an analyte in a sample that can be reliably measured with acceptable bias and precision:
Limit of Quantitation
Day 1 mean: 23 ng/mL
Day 2 mean: 17 ng/mL
Day 3 mean: 21 ng/mL
Day 4 mean: 22 ng/mL
Day 5 mean: 19 ng/mL
Nominal Concentration: 15 ng/mL
What is the Bias(%)?
36%
The coefficient of variation of an analytical method is determined by performing a defined number of replicate assays and then making the following calculation:
Standard deviation divided by the mean and expressed as a percentage
The precision and accuracy in measurement of an analyte under a variety of analytical conditions (e.g., storage conditions):
Robustness
The ability to detect an analyte among a similar class of related compounds or their metabolites:
Method Specificity
This standard and its progeny rely on a “scientific knowledge” approach to determining whether expert testimony is not only relevant, but also reliable, and, therefore, admissible as evidence:
Daubert Standard
Random error plus systematic error equals:
Total Error
The range of analyte where results are proportional to the true concentration of analyte in the sample without modification defines:
Analytical Measure Range
The contamination of a sample(s) or extract(s) caused by a previously run sample or extract:
Carryover
The acronym ISO stands for:
International Organization for Standardization
These studies are conducted to ensure that results reflect the true analyte concentration in a sample:
Accuracy
These studies are conducted to determine the reproducibility of measurements:
Imprecision
Accuracy of a result is based upon these two variables:
Bias and Precision
Defined as the absolute recovery of analyte without use of an internal standard:
Analytical Recovery
