Module 11

Question 1

CO has approximately _____ times greater affinity for Hb than oxygen.

Answer 1

200-300

Question 2

The addition of _____ reduces oxyhemoglobin and methemoglobin to Hb while leaving COHb unaffected.

Answer 2

Sodium hydrosulfite

Question 3

%COHb saturations of _____ are considered normal for smokers.

Answer 3

<10%

Question 4

The presence of a _____ coloration of blood may indicate CO poisoning.

Answer 4

Cherry Red

Question 5

The primary target organ of CN is the _____:

Answer 5

Brain

Question 6

CN levels less than _____ are generally considered to be normal levels.

Answer 6

0.26mg/L

Question 7

CN stops cellular respiration by:

Answer 7

Inhibiting electron transport at the cycochrome c oxidase step

Question 8

Cyanide metabolite:

Answer 8

Thiocyanate

Question 9

Blood CN concentrations above ___ are consistent with death.

Answer 9

3 mg/L

Question 10

Conway cell microdiffusion: CO + palladium chloride = _____

Answer 10

Silver-black mirror color

Question 11

99% of Pb that is absorbed is bound to:

Answer 11

Hb in red blood cells

Question 12

The first signs of a headache may appear at this %COHb level:

Answer 12

10-20%

Question 13

Rhodanese is involved in _____ metabolism.

Answer 13

CN

Question 14

95% of the body burden for Pb is in _____:

Answer 14

Bone

Question 15

The most common initial step in CN analysis is:

Answer 15

Acidification of CN

Question 16

Pb causes increased _____ in the blood.

Answer 16

Zinc protoprophyrin

Question 17

GC detector(s) that can be used to detect CN:

Answer 17

NPD and ECD

Question 18

CO intoxication is considered to be the ultimate cause of death are associated with %COHb saturations of:

Answer 18

> 50%

Question 19

Formation of _____ is an antidote for CN poisoning.

Answer 19

Methemoglobin

Question 20

Major arsenic metabolite:

Answer 20

DMA

Question 21

Mee’s Lines are associated with what type of poisoning

Answer 21

As poisoning

Question 22

Pb causes increased _____ in the urine.

Answer 22

Delta-ALA

Question 23

Dihalomethane metabolism produces:

Answer 23

COHb

Question 24

Vitamin B12 metabolism produces:

Answer 24

CN

Question 25

Potassium CN may be used in the manufacture of:

Answer 25

PCP

Question 26

Stopping of the Kreb’s cycle leases to accumulation of:

Answer 26

Pyruvic acid

Question 27

Black or gray line along the gums is associated with what type of poisoning

Answer 27

Pb poisoning

Question 28

CN antidote:

Answer 28

Nitrite/thiosulfate

Question 29

Arsenic antidote:

Answer 29

BAL

Question 30

What does GFAAS stand for?

Answer 30

Graphite Furnace Atomic Absorption Spectrometry