Module 4.3 Flashcards
role of digestive tract
uptake of nutrients
what are villi
small protrusions for the uptake of different nutrients
role of immune system
variety of cells that differentiate what is ‘good’ or ‘bad’
cells of immune system
Peyers patches, macrophage, mucus, antibodies
hyper inflammation diseases
chrons, arthritis, atherosclerosis
immunoparalysis diseases
sepsis , cancer
good microbes
anaerobic genera
aerobic genrea
anaerobic genera
bifidobacterium
aerobic genera
streptococcus
bad microbes
bacteria
viruses
parasites
bad bacteria e.g.
salmonella
bad virus e.g.
rotavirus
parasite e.g.
giardia intestinalis
roles of microbes
protective = pathogen displacement
structural = IgA induction
metabolic = synthesis of vitamins
pathogenic traits of microbes
promoting colonisation in novel settings
antagonising host defence
most require a range of virulence factors
mechanisms of infection
4 steps
encounter = microbe arrives
entry = binding of receptor which triggers uptake method
replicate = utilise host resource fro multiplication
spread = release of progeny —- DAMAGE
what is gastroenteritis
= inflammation of GI tract
symptoms of gastroenteritis
diarrhoea
vomiting
cramping
what is salmonella
= faecally - orally transmitted bacteria pathogen
what does salmonella cause
enteric fever
INTS
what is systematic dissemination
invades usually sterile sites and grows in a intercellular niche
e.g. spleen, liver, bone marrow
what is gut lumen
luminal space provides extracellular niche for growth
Innate immune cells
dendritic
macrophage
mast cell
NKC
granulocyte
adaptive immune cells
B cell
T cell
antibodies
CD4+ cells
CD8+ cells
