module 4- male reproduction, sex determination, mating Flashcards
sexual dimorphism & example
distinguishes members of same species by sex
- size
T or F: sexual dimorphic traits are low in numbers
T
sex differences & example
differences in average of a phenotype between males & females
- height
T or F: females & males have same hormones but produced in diff amounts
T
sex of an animal
the ability to produce a particular type of gamete along with any associated phenotypic traits
intersex individuals
animals born with varying presentations of male & female genitalia
example of intersex animal
honeycreeper
sex determination
process of development of ovaries or testes from embryonic gonad
why can you have sex reversal?
b/c the integration of community cell fates are not set in stone
GSD vs ESD
GSD- genetic sex determination, depends on sex chromosomes, most common way
ESD-environmental sex determination, no sex chromosomes, depends on external factors
mammals/frogs, birds/amphibians & insects genotype for males vs females
mammals/frogs: XY = male
amphibians/birds: ZZ male
insects: XO = male
what is the oldest known animal for sex chromosomes
octopus (XX=male)
1st, 2nd & 3rd trimester major events
1) fertilization
2) sex determination
3) testicular descent
primordial germ cells
stem cells that are capable of becoming egg or sperm
T or F: yolk sac is for blood cell development
T
what occurs when yolk sac is abolished?
primordial germ cells move back into the embyro
how do primordial germ cells move?
migrate as a group from allantois -> hindgut
what 2 things do somatic cells around primordial germ cells secrete?
chemoattractants - help PGCs induce migration and survival factors
teratomas
tumours that form when PCGs grow outside genital ridge = can grow teeth & hair b/c these cells have potential for development
what is the genital ridge & where does it form?
where gonads develop, forms near embryonic kidneys
bipotential gonad
development is unknown but can become ovary or testes later
primitive sex cords
compact strands of tissue that incorporate PGCs & allow formation of gonad
paramesonephric duct
mullerian duct
T or F: no single factor is responsible for activation of ovary or testes development in ALL vertebrates
T
SRY gene
stimulates production of a protein called TDF, females lack this gene
phenotypic sex
visual anatomic sex of an individual, depends on presence or absence of testes
what do wolffian ducts develop into?
the male reproductive tract
anti-mullerian hormone function
inhibits female duct system
testosterone is reduced to what?
DHT- dihydrotestosterone
FOXI2 vs SOX9 gene function
FOX-drives development of ovaries
SOX-produces antimullerian hormone
T or F: social stress from lack of male = cause female to form into male to fertilize the females egg
T
epigenic regulation
altering gene expression & phenotype without changing DNA sequence- genes get methylated (respressed)
how does sex determination work in turtle eggs in sand?
higher temperature forms females = demethylation (activation) of FOXI2
STAT-3 function
roles in temp & stress responses that lead to sex determination
cumulative process
long developmental window so changing fertilized eggs between temperatures can switch sexual development until specific development of gonads
why do gonads need a tightly regulated network of transcription factors & cell signalling molecules?
b/c disorders of sex development (DSDs) can occur
- infertility & dysfunction
polled intersex syndrome
a deletion in chromosome 1 that effects polled gene & FOXI2
- FOXI2: need 2 copies for effects
- polled: only need 1 copy
polled intersex goat phenotype for heterozygous male, infertile phenotypic male & phenotypic male
heterozygous male- polled & 1 FOXI2 gene
infertile phenotypic male- no FOXI2 gene, polled
phenotypic female: polled, 1 copy of FOXI2
turners syndrome
only 1 chromosome is present
hypoplastic ovary
underdeveloped ovary & small uterus
gonadal dysgenesis
lack of proper genes occurs when 1 X chromosome is present
infantile result from
lack of gonadal hormones
klinefelters syndrome
occurs from non-disjunction during meiosis
XXX female infertile
true parthenogenesis occurs in
females
how many species use parthenogenesis
80
obligate vs facultative parthenogenesis
obligate: only asexual reproduction
facultative: only sometimes uses sexual if stressed
why do mammals not use facultative parthenogenesis
mammals use genomic imprinting and require maternal genes & specific male genes at specific times
T or F: stingray can use parthenogenesis
T
obligate parthenogenesis
doubling of chromosomes in diploid state so they can replicate or fuse = creates diploid cell when normally a haploid would be formed
facultative parthenogenesis
diploid chromosome is restored by failure of 2nd meiotic division
what occurs if meiosis 2 division does occur in facultative parthenogenesis
polar body will fuse back with haploid & produce diploid
what structure allows germ cells to get incorporated into testes
from seminiferous tubules
how do testes develop
PCGs become incorporated in epithelial sex cords and driven by the presence of the Y chromosome
what is the mesonephros
transient form of the embryonic kidney that will not become the adult kidney
- it is used to produce the reproductive system when the adult kidney comes in
where is the anti-mullerian hormone secreted from?
sertoli cells
rete testis
network connecting cords so sperm can move into urethra
seminiferous cords
solid tubules that contain the germ cells - each one contains approx. 4 germ cells
what do interstitial cells produce
testosterone
excurrent extrgonadal duct system
direct tubular connection from place where sperm are produced to urethra, fluid is there to allow sperm to be flushed towards urethra as needed
what are seminiferous tubules developed from? what does it connect
developed from seminiferous cords, connects rete testis & efferent ducts
what indicates puberty
age
what animal reaches puberty earliest vs latest
earliest-sheep
latest-humans
what temp do testes require for spermatogenesis to occur
2-4 C below body temp
cryptorchidism
undescended testes, cannot modulate temp properly for spermatogenesis
where does spermatogenesis take place
seminiferous tubules
T or F: more mature sperm move slowly
T
gubernaculum
retracts to pull testes into scrotal sacs
how do aquatic animals with fins modulate testes temp?
fins have vascular supply that is cooled in flipper region & goes to testes first before rest of body so it doesn’t warm up- no scrotal sac
T or F: elephants do not have testicular descent
T
unilateral vs bilateral cryptorchidism
unilateral-failure of 1 testes to descend, low fertility, most common
bilateral- failure of both testes to descend, infertile
disadvantage of cryptorchidism
testosterone is still produced so can have intact male behaviour but actual spermatogenesis does not occur
2 ways cryptorchidism can be diganosed
ultrasound or radiograph
what is the most common disorder of sexual differentiation in humans
cryptorchidism
why should undescended testes be removed?
b/c they can develop into tumours & still produce testosterone = intact male behaviours
effects of testosterone before & after birth
before: masculinizes reproductive tract & descent of testes
after: growth & maturation of reproductive system & spermatogenesis