endocrine pathways Flashcards
thyroid hormone secretion
hypothalamus, TRH, anterior pituitary, TSH, thyroid gland, TH, target cells, circulation, BMR & body temp effects
growth hormone secretion
hypothalamus, GnRH / GHIH -> anterior pit -> GH -> adipose, muscle, iver -> IGF-1
stress comand pathway
stress -> hypothalamus -> CRH -> ant pit -> ATCH -> adrenal cortex -> cortisol -> most cells -> metabolic changes
calcitonin/PTH pathway
low plasma Ca -> PTH -> increase PTH -> increase plasma Ca
high plasma Ca -> thyroid cells -> increase calcitonin -> decrease plasma Ca
osteoblast pathway
osteoblasts -> RANK ligand or OPG
RANK ligand -> macrophages -> increase osteoclast action -> decrease bone mass
OPG -> rank ligand bound to OPG -> blocks RANK action -> decreased osteoclast action -> increased bone mass