Module 4-6 TBL Questions Flashcards

1
Q

Which hormones do thyroid follicular cells secrete?

A

thyroxine and triiodothyronine

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2
Q

What ion is required to produce thyroid hormone?

A

iodide

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3
Q

Which protein molecule is used to synthesize thyroid hormone?

A

thyroglobulin

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4
Q

The majority of triiodothyronine travels bound to:

A

thyroxine binding globulin

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5
Q

How long can thyroid follicles store thyroid hormones?

A

2-3 months

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6
Q

What is the storage form of thyroid hormone?

A

T4

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7
Q

What enzyme is required to oxidize iodide?

A

peroxidase

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8
Q

Which thyroid hormone is released into circulation about every 24 hours?

A

T3

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9
Q

Which AA is required to produce thyroid hormone?

A

tyrosine

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10
Q

Which substance converts the storage form of thyroid hormone into the bioactive form?

A

thyroid deiodinase

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11
Q

What is the primary function of thyroid hormone?

A

increase metabolism

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12
Q

Normal levels of thyroid hormone effect the following EXCEPT:
A) CNS activity
B) bone growth
C) depletion of B vits
D) increases rate and depth of respiration
E) cardiac output

A

C) depletion of B vits

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13
Q

Which condition increases serum cholesterol?

A

hypothyroidism

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14
Q

Which condition leads to weight gain with loss of appetite?

A

hypothyroidism

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15
Q

Why is normal levels of thyroid hormone helpful for you to do well on national board exams?

A

it will increase your ability to think, reason, and make judgements

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16
Q

Which enzyme cleaves iodine from unreleased thyroid hormone to be recycled?

A

deiodinase

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17
Q

What is the main component of the colloid substance inside a thyroid follicle?

A

thyroglobulin

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18
Q

Thyroid follicles are formed from

A

cuboidal epithelium

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19
Q

The hypothalamus secretes ________ which stimulates the anterior pituitary to secrete _________ which stimulates the thyroid gland to produce thyroid hormone

A

TRH, TSH

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20
Q

Which condition can cause polymenorrhea?

A

hyposecretion of thyroid hormone

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21
Q

Which condition will show TSAb or TSI in plasma?

A

Grave’s disease

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22
Q

What is the incidence of hyperthyroidism?

A

4 female: 1 male

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23
Q

Why is it difficult to diagnose early stages of Hashimoto’s disease?

A

damaged follicular cells dump stored thyroid hormones into circulation

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24
Q

What is the mechanism of cell destruction in Hashimoto’s?

A

lymphocytes destroy follicular cells

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25
Q

A person with Grave’s disease will have blood test showing:

A

low TSH and high thyroid hormones (T3/T4)

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26
Q

Does hyperthyroidism or hypothyroidism have exophthalmos?

A

hyperthyroidism

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27
Q

Does hyperthyroidism or hypothyroidism have weight gain despite decreased appetite?

A

hypothyroidism

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28
Q

Does hyperthyroidism or hypothyroidism have diarrhea?

A

hyperthyroidism

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29
Q

Does hyperthyroidism or hypothyroidism have brain fog?

A

hypothyroidism

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30
Q

Does hyperthyroidism or hypothyroidism have thinning hair?

A

hypothyroidism

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31
Q

Does hyperthyroidism or hypothyroidism have mild tremors?

A

hyperthyroidism

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32
Q

Does hyperthyroidism or hypothyroidism have insomnia?

A

hyperthyroidism

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33
Q

Does hyperthyroidism or hypothyroidism have bradycardia?

A

hypothyroidism

34
Q

Does hyperthyroidism or hypothyroidism have heat intolerance?

A

hyperthyroidism

35
Q

What is the most common cause of hyperthyroidism?

A

Grave’s disease

36
Q

What is the most severe and life threatening form of hypothyroidism?

37
Q

What is the primary cause of endemic goiter?

A

decreased dietary iodide

38
Q

Grave’s disease and Hashimoto’s are both a result of

A

an autoimmune disorder

39
Q

What does TRH bind to on the thyrotropic cells?

40
Q

What is the HPA of thyroid hormone?

A

hypothalamus secretes TRH which stimulates the anterior pituitary to secreted TSH which stimulates the thyroid gland to produce thyroid hormone

41
Q

Grave’s disease involves TSI stimulating the thyroid follicle to produce thyroid hormone for about _______ hours

42
Q

These conditions manifest a goiter EXCEPT:
A) myxedema
B) Grave’s
C) Hashimoto’s
D) Cretinism

A

D) Cretinism

43
Q

Which combination forms thyroxine?
A) MIT and DIT
B) DIT and DIT
C) MIT and MIT

A

B) DIT and DIT

44
Q

Why would a patient with long term hyperthyroidism present with decreased muscle tone?

A

excessive protein catabolism

45
Q

Which condition causes high serum peroxidase antibody?

A

Hashimoto’s

46
Q

How does thyroid hormone affect the body in general?

A

increase metabolism

47
Q

How will an increase in TRH affect the body?

A

increase TSH and increase T3/T4 levels

48
Q

Which condition can cause high blood levels of cholesterol leading to atherosclerosis?

A

hypothyroidism

49
Q

What is the embryonic origin of the adrenal medulla?

A

neural crest cells

50
Q

The ________________ acts like a post-ganglionic axon releasing hormones into the bloodstream

A

adrenal medulla

51
Q

Which structure produces androgens?

A

zona reticularis

52
Q

Which structure produces aldosterone?

A

zona glomerulosa

53
Q

Which structure produces cortisol?

A

zona fasciculata

54
Q

These hormones are secreted when stimulated by ACTH EXCEPT:
A) androgens
B) cortisol
C) aldosterone

A

C) aldosterone

55
Q

Overproduction of which hormone stimulates skin melanocytes?

56
Q

Chronic hyper-secretion of this hormone can cause death of hipoocampal neurons

57
Q

Which hormone is released by ang II stimulation?

A

aldosterone

58
Q

From which substance are all adrenal cortex hormones synthesized?

A

cholesterol

59
Q

Which hormone is a glucocorticoid?

60
Q

Which adrenal structure produces NE and epi?

A

Adrenal medulla

61
Q

What is another name for cortisol binding globulin that binds to cortisol in circulation?

A

transcortin

62
Q

What is a cause of Addison’s disease?

A

autoimmune destruction of the adrenal cortex

63
Q

Which hormone increases LDL receptors on the adrenal cortex membrane?

64
Q

What specifically causes Cushing’s syndrome signs and symptoms?

A

hypersecretion of cortisol and androgens

65
Q

The hypothalamus secretes _______ which stimulates the anterior pituitary to secrete _________ which stimulates the adrenal to produce androgens and ____________

A

CRH, ACTH, cortisol

66
Q

Hypersecretion of __________ is responsible for the moon face edema associated with Cushing’s syndrome

67
Q

Do patients with Addison’s disease or Cushing’s syndrome have high BP?

A

Cushing’s

68
Q

Do patients with Addison’s disease or Cushing’s syndrome have vertebral body compression fractures?

A

Cushing’s

69
Q

Do patients with Addison’s disease or Cushing’s syndrome have over-active immune system?

A

Addison’s

70
Q

Do patients with Addison’s disease or Cushing’s syndrome have hyperkalemia?

A

Addison’s

71
Q

Do patients with Addison’s disease or Cushing’s syndrome have hyponatremia?

A

Addison’s

72
Q

Do patients with Addison’s disease or Cushing’s syndrome have hyperglycemia?

A

Cushing’s

73
Q

Do patients with Addison’s disease or Cushing’s syndrome have decreased collagen production?

A

Cushing’s

74
Q

Do patients with Addison’s disease or Cushing’s syndrome have low blood volume?

A

Addison’s

75
Q

Do patients with Addison’s disease or Cushing’s syndrome have a copper tint to skin?

A

Addison’s

76
Q

Do patients with Addison’s disease or Cushing’s syndrome have a buffalo hump?

A

Cushing’s

77
Q

Which condition is caused by a tumor of cortiotropic cells?

A

Cushing’s syndrome

78
Q

High plasma levels of this ion can stimulate the secretion of aldosterone?

79
Q

What is the primary cause of purple striae associated with hypercortisolism?

A

decreased collagen production

80
Q

How can Addison’s disease affect serum cholesterol?

A

increase serum cholesterol due to lack of LDL receptors on adrenal cortex