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MEDL 310 > Module 4 > Flashcards

Module 4 Flashcards

1
Q

What are the principal lymphoid organs?

A

Thymus, lymph nodes, spleen

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2
Q

What is the first lymphoid organ produced?

A

Thymus

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3
Q

What is the purpose of the thymus?

A

T-lymph maturation

Production of thymic hormones

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4
Q

What protects and supports the thymus?

A

Fibrous connective tissue (capsule) protects

Septa/trabeculae extend into the matrix, divides into lobules

Main support from underlying network of reticulin fibres

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5
Q

What are the characteristics of the thymic cortex?

A

Outer layer- deep staining

Large T lymph population

Only have efferent vessels

Epithelial reticular (nurse) cells- produce thymosin

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6
Q

What are the characteristics of the thymic medulla?

A

Inner layer- pale staining

Mesh work of epithelial cells (Hassall’s corpuscles) represent degenerative phenomenon

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7
Q

What are the functions of lymph nodes?

A

Filtration of lymph (macrophages)

Storage and proliferation of B and T lymphs

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8
Q

What is the purpose of trabeculae in the lymph nodes?

A

Provide support and convey large blood vessels

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9
Q

What are the characteristics of the interior lymph nodes?

A

Network of fine reticular fibres (support the cells)

Afferent lymphatics to subcapsular sinus to medullary sinuses (via cortical sinuses), exit through hilum

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10
Q

What are the characteristics of the lymph node cortex?

A

Densely packed lymphs

Extensions- medullary cords project into medullary space

Lymphoid follicles- germinal centred, proliferation of B lymphs

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11
Q

What are the characteristics of the cortical zone/paracortex?

A

Mainly T-lymphs

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12
Q

What happens to a lymph node when cellular or humoral responses are activated?

A

Cellular- paracortical thickening

Humoral- follicular thickening

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13
Q

What are the characteristics of the lymph node medulla?

A

Aggregations of B lymphs and plasma cells

Medullary sinuses between cords

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14
Q

What are the vessels involved in the spleen?

A

Received from splenic artery

Drained from splenic vein

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15
Q

What are the functions of the white and red pulp?

A

White- aggregations of lymphoid tissue, antibody formation

Red- filters blood and removes damaged red blood cells by macrophages, endothelial/stave cells lines vessels that move blood between venous sinuses

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16
Q

What are the main lines of defence against invading pathogens?

A

Protective surface phenomena (skin)

Nonspecific cellular responses (innate- macrophages and neutrophils)

Specific immune responses (adaptive- antibody production)

MEDL 310 (10 decks)

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