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VIROLOGY > Module 3 > Flashcards

Module 3 Flashcards

1
Q

Innate or Adaptive:
Provides constant and relatively rapid protection

A

Innate Immunity

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2
Q

Innate or Adaptive:
Previous exposure not required to be activated

A

Innate Immunity

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3
Q

Innate or Adaptive:
Cells does not respond to specific viral antigens

A

Innate Immunity

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4
Q

Innate or Adaptive:
Cells are activated by the presence of the virus

A

Innate Immunity

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5
Q

Innate or Adaptive:
Develops only after exposure to a virus

A

Adaptive Immunity

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6
Q

Innate or Adaptive:
Specific to that particular pathogen and close relatives

A

Adaptive Immunity

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7
Q

Innate or Adaptive:
Involves cell and antibody mediated effector mechanism

A

Adaptive Immunity

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8
Q

Innate or Adaptive:
Includes the T and B lymphocytes

A

Adaptive Immunity

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9
Q

Innate or Adaptive:
Exhibits a memory property

A

Adaptive Immunity

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10
Q

Innate or Adaptive:
Quickly reactivated after re-exposure

A

Adaptive Immunity

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11
Q

Innate or Adaptive:
Includes the production of cytokines

A

Innate Immunity

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12
Q

These are cytokines made by lymphocytes

A

Interleukins

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13
Q

These are key family of cytokines

A

Interferons

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14
Q

Are key elements of antiviral resistance at the cellular level.

A

Interferons

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15
Q

These protein hormones bind to the IFN-α receptor

A

Type I interferon (IFN)/ IFN-α.

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16
Q

Activates the signaling cascade that results to induction of the interferon response genes in cells

A

Type I interferon (IFN)/ IFN-α.

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17
Q

Cytokine central to both innate and adaptive immunity.

A

Type II interferon or IFN- γ

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18
Q

Also known as Immune interferon

A

Type II interferon or IFN- γ

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19
Q

Defines multiple subtypes of T Lymphocytes.

A

Type II interferon

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20
Q

Designated as IFN-λ (lambda)

A

Type III

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21
Q

IFN- γ is what type of Interferon

22
Q

Type I Interferon are activated via cel/lular receptors called

A

Pattern Recognition Receptors

23
Q

These detects pathogen-associated molecules patterns (PAMPs) specific to different classes of viruses

A

Pattern Recognition Receptors (TLRs)

24
Q

TRUE or FALSE:
Binding of PAMPs to PRRs stimulates the transcription of numerous genes encoding proteins involved in innate and immune responses including interferon.

25
Q

Toll-like receptors that bind ssRNA, detect RNA virus infections

A

TLR7 & TLR8

26
Q

Toll-like receptors that detects dsRNA

27
Q

Type I interferon released from virus-infected cells or activated innate response cells stimulates adjacent cells via what?

A

INFAR (Interferon-alpha/beta receptor)

28
Q

These specialized lymphocytes lack an antigen-specific receptor

A

Natural Killer Cells

29
Q

Natural Killer Cells can kill virus-infected cells, tumor cells and other cells they detect to be in a state of what?

A

State of Stress

30
Q

These expresses an extensive complex of receptors that recognize PAMPs

A

Natural Killer CElls

31
Q

TRUE or FALSE:
Natural Killer cells binds to MHCII complex proteins

32
Q

TRUE or FALSE:
Common effect of virus infection is reduced expression of class II MHC on surface of infected cells

A

FALSE:
Class I MHC

33
Q

TRUE or FALSE:
NK cells kill virus-infected cells by inducing apoptosis

34
Q

Natural Killer Cells are very efficient at production and secretion of what type of Interferon?

A

Type II interferon

35
Q

They are critical to the initiation of the adaptive immune response but also central to innate immunity.

A

Dendritic Cells

36
Q

They express a high density of Class II MHC proteins

A

Dendritic Cells

37
Q

They are highly phagocytic in the naive state

A

Dendritic Cells

38
Q

TRUE or FALSE:
Dendritic cells can also respond to stimulation by PAMPs by secreting Type I Interferon

39
Q

What are the Dendritic Cells of the skin?

A

Langerhans Cells

40
Q

What immunity is mediated by antibodies secreted by terminally differentiated B lymphocytes

A

Humoral Immunity

41
Q

Differentiated B lymphocytes are called?

A

Plasma Cells

42
Q

What immunity is driven by alpha and beta T cell receptor expressing lymphocytes

A

Cell-mediated Immunity

43
Q

TRUE or FALSE:
Classical Dendritic cells are professional antigen presenting cells

44
Q

This type of immunity is mediated by antibodies

A

Humoral Immunity

45
Q

Antibody found primarily in blood; first antibodies produced.

46
Q

Principal class of Antibody in blood and extracellular fluid.

47
Q

The main antibody secretion in the respiratory, genital and the GIT

48
Q

Antibody that are very low concentration in the blood and ECF

49
Q

Antibody that mediates allergic reactions

50
Q

This antibody is expressed almost exclusively as a cell surface molecule by naive B cells

VIROLOGY (14 decks)

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