Asfarviridae Flashcards
What is the only genus under the family Asfarviridae?
Asfivirus
What is the sole member of the genus Asfivirus?
African swine fever virus (ASFV)
ASFV is the only known DNA arbovirus transmitted by what arthropod?
Soft ticks of the genus Ornithodoros
Is ASFV an enveloped or non-enveloped virus?
Enveloped
What is the structure of the ASFV virion?
Nucleocapsid core, surrounded by lipid layers and a hexagonal icosahedral capsid
What is the genome structure of ASFV?
Double-stranded DNA
Where does ASFV viral replication primarily occur?
Cytoplasm, but nucleus is needed; “nucleocytoplasmic”
What viral process involves the nucleus in ASFV replication?
Viral DNA synthesis
How does ASFV enter host cells?
Receptor-mediated endocytosis
Which ASFV proteins facilitate attachment to host cells?
p72 and p54
What viral protein is involved in ASFV internalization?
p30
What structures are produced in the cytoplasm during late infection?
Paracrystalline arrays of virions
How are ASFV virions released from the host cell?
Budding through microvillus-like projections
What cells are primarily targeted by ASFV?
Macrophages and endothelial cells
What are common signs of acute African swine fever?
High fever, lethargy, anorexia, hemorrhages, cyanosis, and high mortality
What is used to control soft tick populations where ASFV is present?
Acaricides
Asfarviridae is known to be stable in the environment ranging in what temperature?
4-20°C
African Swine Fever is endemic in?
Sub-saharan Africa
What protein is used for genotyping the African Swine Virus
p72/p73
