MODIFIED RELEASE Flashcards
Used to describe dosage forms having drug release features based on; time, course, location that are designed to accomplish therapeutic
MODIFIED RELEASE
- Dosage form allows a reduction in dosing frequency
- drug is released slowly
EXTENDED RELEASE
- Release the drug from the dosage form at a time other than promptly after administration
- enteric coated
DELAYED RELEASE
Contain two doses of medication, one for immediate release and the second for delayed release
repeat action
The release of a drug from an oral dosage form may be intentionally delayed until it reaches the intestines for several reasons
- protect drug from gastric fluids
- reduce gastric distress
- facilitate GI transit
use for coating enteric coated tablets (5)
fats
fatty acids
waxes
shellac
cellulose acetate phthalate
breaking down in the less acidic environment of the intestine
pH dependent
eroding by moisture over time during gastrointestinal transit
time dependent
deteriorating as a result of the hydrolysis-catalyzing action of intestinal enzymes
enzyme dependent
tablet’s outer shell or coating
immediate release
tablet’s inner core separated by a slowly permeable barrier coating
second release
Drug from the inner core is exposed to body fluids and release ____ hours after administration
4 - 6 hours
Repeat action dosage forms are best suited for the treatment of ____ conditions requiring repeated dosing
chronic
The drugs utilized should have ____ dosage and fairly rapid rates of ____ and ____.
low
absorption
excretion
Drug release directed toward isolating or concentrating a drug in a body region, tissue, or site for absorption or for drug action
targeted release
The drug is distributed into beads, pellets, granules or other particulate system
coated beads, granules, and microspheres
COATED BEADS, GRANULES AND MICROSPHERES
Drug is coated onto inert beads (____, ____ or -
____)
starch
sugar
microcrystalline cellulose
COATED BEADS, GRANULES AND MICROSPHERES
Then, the beads are coated with a lipid material (____, ____, ____ or ____)
beeswax
carnauba wax
glyceryl monostearate
cetyl alcohol
COATED BEADS, GRANULES AND MICROSPHERES
Then, the beads are coated with a cellulosic material like ____
ethylcellulose
COATED BEADS, GRANULES AND MICROSPHERES
Granules will be placed in ____ or ____
capsules or tablets
COATED BEADS, GRANULES AND MICROSPHERES
are also used as coating material such as ethyl cellulose and plasticizer
aqueous coating systems
COATED BEADS, GRANULES AND MICROSPHERES
The thicker the coat the more ____ top penetration more delay on drug release and dissolution
more resistant
- Small spheroid compressing tablets 3 to 4 mm in diameter
- Placed in gelatin capsule shell to provide the desired pattern of drug release
- Each capsule contain 8 to 10 mini tablets
- Uncoated for immediate release and other coated for extended release
multitablet system
MULTITABLET SYSTEM
size in diameter
3 to 4 mm
MULTITABLET SYSTEM
each capsule contain ____ to ____ mini tablets
8 - 10
MULTITABLET SYSTEM
____ fro immediate release
uncoated
MULTITABLET SYSTEM
____ for extended release
other coated