Mod 1 antivirals Flashcards

antivirals

1
Q

acyclovir indications

A

herpes zoster (shingles)
genital herpes
varicella
cold sores and genital sores

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

acyclovir mechanism of action

A

DNA polymerase inhibitor
terminates DNA chain during replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

acyclovir administration consideration

A

nephrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

antiviral patient education

A

significant fatigue
periods of rest encouraged

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

antiInfluenza generic med

A

oseltamivir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

oseltamivir MOA

A

prevents release of virus from infected cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

oseltamivir administration considerations

A

decreases sx and shortens duration but doesn’t cure flu
start treatment w/in 48h of sx onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

antiretrovirals indications

A

illnesses like HIV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

antiretrovirals MOA

A

impede replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

antiretrovirals administration considerations

A

impact renal fxn
monitor urine output and renal labs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

acyclovir patient education

A

avoid sexual contact while lesions are present
fluid intake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

acylclovir route

A

PO
IV
topical
NEVER IM OR SUBQ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

acyclovir therepeutic effects

A

not a cure, improves sx
long term for prevention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

acyclovir side effects

A

GI distress (taken on empty stomach)
burning upon application

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

acyclovir adverse effects

A

renal impairment
neuro problems
dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

oseltamivir side effects

A

GI distress (empty stomach)
skin/hypersensitivty reactions (DISCONTINUE)

17
Q

anti-hepatitis drug

A

adefovir

18
Q

adefovir administration considerations

A

PO
prolonged therapy based on patient status
can promote resistence to antiretrovirals if untreated HIV infx

19
Q

adefovir therepeutic effects

A

maintains or improves liver fx while active disease is present

20
Q

adefovir SE and AE

A

exacerbation of Hep B
nephrotoxicity
lactic acidosis
severe hepatomegally

21
Q

Lamivudine-zidovudine indications

A

HIV- and1 HBV
decreases chance of acquiring AIDS and HIV related illnesses

22
Q

Lamivudine-zidovudine administration considerations

A

higher dose for HIV
caution with renal impairment
HIV complications may still occur
transmission is still possible

23
Q

Lamivudine-zidovudine SE/AE

A

lactic acidosis
severe hepatomegally
pancreatitis (DISCONTINUE)

24
Q

triple-drug therapy for HIV

A

protease inhibitors (PIs)
Nucleoside reverse transcriptase inhibitors (NRTIs)
Non-nucleoside reverse transcriptase inhibitors
(NNRTIs)

25
Q

lab monitoring for HIV

A

viral load (plasma HIV)
CD4 T-cell counts
Liver fx tests (LFTs)
CBC