Mod 1 antivirals

Question 1

acyclovir indications

Answer 1

herpes zoster (shingles)
genital herpes
varicella
cold sores and genital sores

Question 2

acyclovir mechanism of action

Answer 2

DNA polymerase inhibitor
terminates DNA chain during replication

Question 3

acyclovir administration consideration

Answer 3

nephrotoxicity

Question 4

antiviral patient education

Answer 4

significant fatigue
periods of rest encouraged

Question 5

antiInfluenza generic med

Answer 5

oseltamivir

Question 6

oseltamivir MOA

Answer 6

prevents release of virus from infected cells

Question 7

oseltamivir administration considerations

Answer 7

decreases sx and shortens duration but doesn’t cure flu
start treatment w/in 48h of sx onset

Question 8

antiretrovirals indications

Answer 8

illnesses like HIV

Question 9

antiretrovirals MOA

Answer 9

impede replication

Question 10

antiretrovirals administration considerations

Answer 10

impact renal fxn
monitor urine output and renal labs

Question 11

acyclovir patient education

Answer 11

avoid sexual contact while lesions are present
fluid intake

Question 12

acylclovir route

Answer 12

PO
IV
topical
NEVER IM OR SUBQ

Question 13

acyclovir therepeutic effects

Answer 13

not a cure, improves sx
long term for prevention

Question 14

acyclovir side effects

Answer 14

GI distress (taken on empty stomach)
burning upon application

Question 15

acyclovir adverse effects

Answer 15

renal impairment
neuro problems
dehydration

Question 16

oseltamivir side effects

Answer 16

GI distress (empty stomach)
skin/hypersensitivty reactions (DISCONTINUE)

Question 17

anti-hepatitis drug

Answer 17

adefovir

Question 18

adefovir administration considerations

Answer 18

PO
prolonged therapy based on patient status
can promote resistence to antiretrovirals if untreated HIV infx

Question 19

adefovir therepeutic effects

Answer 19

maintains or improves liver fx while active disease is present

Question 20

adefovir SE and AE

Answer 20

exacerbation of Hep B
nephrotoxicity
lactic acidosis
severe hepatomegally

Question 21

Lamivudine-zidovudine indications

Answer 21

HIV- and1 HBV
decreases chance of acquiring AIDS and HIV related illnesses

Question 22

Lamivudine-zidovudine administration considerations

Answer 22

higher dose for HIV
caution with renal impairment
HIV complications may still occur
transmission is still possible

Question 23

Lamivudine-zidovudine SE/AE

Answer 23

lactic acidosis
severe hepatomegally
pancreatitis (DISCONTINUE)

Question 24

triple-drug therapy for HIV

Answer 24

protease inhibitors (PIs)
Nucleoside reverse transcriptase inhibitors (NRTIs)
Non-nucleoside reverse transcriptase inhibitors
(NNRTIs)

Question 25

lab monitoring for HIV

Answer 25

viral load (plasma HIV) CD4 T-cell counts Liver fx tests (LFTs) CBC