Mod 1 antifungals Flashcards
azole antifungals
imidazoles
triazoles
mycoses
illnesses caused by fungi
Imidazoles
miconazole
ketonazole
clotrimazole
treat fungal skin infections
(tinea pedis, tinea curtis, tinea corporis)
triazole
PO and IV
systemic yeast infx (oral thrush, cryptococcal meningitis)
selective toxicity
fewer side effects
allylamines (topical)
treatment of dermatophytic skin infx (tinea pedis, ringworm, tinea cruris)
allylamines (PO)
terbinafine
terbinafine
fingernail and toenail fungus
SE of hepatotoxicity
polyenes
structurally similar to macrolides
made by actinomycete soil bacteria
amphotericin B and nystatin
Nystatin
topical treatment for yeats infx of skin, mouth, vagina
intestinal fungal infx
amphotericin B
systemic fungal infx like asperigillosis, cryptococcla meningitis, histoplasmosis, blastomycosis, candidiasis
serious SE, nephrotoxic
antifungal MOA
disrupt ergosterol biosynthesis of membrane
increase permeability, cell death
antifunal patient education
report skin rash, abdm px, fever, diarrhea
monitor for bruising or bleeding (liver dysfx)
clotrimazole
topical (2xdaily)
tinea pedis
tinea cruris
ringworm
SE/AE skin irritation and rash
fluconazole
PO/IV
caution if liver dysfx, pregnancy
improves yeast infx symptoms
SE/AE hepatotoxic
terbinafine
cream, aerosol (on CLEAN, DRY skin)
tinea pedis
tinea cruris
ringworm
external use only
