Mod 1 antituberculars

Question 1

MOA

Answer 1

impact synthesis of RNA
inhibit synthesis of mycolic acids in wall

Question 2

administration considerations

Answer 2

at least 6mo treatment (up to 2y)
impact liver fx
monitor liver enzymes
avoid alcohol
tune and swiss cheese (tyramine)

Question 3

generic drug

Answer 3

isoniazid

Question 4

isoniazid administration considerations

Answer 4

may require DOT
individualized based on susceptibility
B6 to decrease risk of peripheral neuropathy

Question 5

isoniazid SE/AE

Answer 5

GI upset
hepatotoxicity
decrease effectiveness of oral contraceptives

Question 6

drug-sensitive regimen

Answer 6

(daily)
isoniazid
rifampin
pyrazinamide
ethambutol

Question 7

AE of drug regimen

Answer 7

bodily fluid discolaration
hepatitis
optic neuritis
allergy
hyperuricemia

Question 8

therapy continutation phase

Answer 8

rifampin and isoniazid
daily or biweekly
4-10mo