MNSs Blood Group

Question 1

Found on Glycophorin A
Well developed at birth
Easy destroyed by enzymes

Answer 1

MN antigen

Question 2

MN antigens differ in their Amino acid positioned at

Answer 2

1 and 5

Question 3

M antigen amino acid

Answer 3

Serine
Glycine

Question 4

N antigen amino acid

Answer 4

Leucine
Glutamic acid

Question 5

Located on Glycophorin B
Less easily destroyed by enzymes

Answer 5

Ss antigen

Question 6

Ss antigen is positioned @ GPB

Answer 6

29

Question 7

Ss antigens

S amino acid

Answer 7

Methionine

Question 8

s antigen

Answer 8

Threonine

Question 9

Enhanced by acidification

Answer 9

Anti-M

Question 10

Lectin for Anti-M

Answer 10

Iberis Amara

Question 11

Naturally Occurring : Cold Reactive
IgM or IgG
pH-dependent (6.5)
Enhanced with Glucose solution

Answer 11

Anti-M

Question 12

Clinical Significance of Anti-M

Answer 12

HTR
HDN

Question 13

Naturally-occurring
IgM or IgG
Do not bind Complement
rare cause pf HDN

Answer 13

Anti-N

Question 14

Found in patient with Renal Diseases,, dialyzed with sterilized FORMALDEHYDE

Answer 14

Anti-N

Question 15

Mostly IgG
Reacts @37 deg cel (AHG Phase)
Severe HTR and HDN

Answer 15

Anti-S and Anti-s

Question 16

Found in S-s individuals
IgG in nature
Severe HTR and HDN
COMMON IN BLACKS

Answer 16

Anti-U

Question 17

GPA and GPB DEFICIENT PHENOTYPE:

Found in M- N- individuals
With anti-En^a

Answer 17

En (a-)

Question 18

GPA and GPB DEFICIENT PHENOTYPE:

M-N-S-s-U-En(a-)-Wr(a- b-)
Normal hematologic pixture

Answer 18

Mk phenotype

Question 19

GPA and GPB DEFICIENT PHENOTYPE:

S-s-U

Answer 19

U phenotype