ABO Flashcards
Universal Blood Recipient
AB
Universal Blood Donor
O
Universal Plasma Donor
AB
Universal Plasma Recipient
O
ABO Chromosome
9
H chromosome
19
Major ABO Genotypes and Phenotypes:
A1
A1A1
A1O
A1A2
Major ABO Genotypes and Phenotypes:
A2
A2A2
A2O
Major ABO Genotypes and Phenotypes:
A1B
A1B
Major ABO Genotypes and Phenotypes:
A2B
A2B
Major ABO Genotypes and Phenotypes:
B
BB, BO
Major ABO Genotypes and Phenotypes:
O
OO
Formation of ABH Antigens
Glycosyltransferase:
Immunodominant sugar:
H
L-fucosyltransferase
L-fucose
Formation of ABH Antigens
Glycosyltransferase:
Immunodominant sugar:
A
N-acetylgalactosaminyltransferase
N-acetyl-D-galactosamine
Formation of ABH Antigens
Glycosyltransferase:
Immunodominant sugar:
B
D-galactosyltransferase
D-galactose
Formation of ABH Antigens
Glycosyltransferase:
Immunodominant sugar:
AB
N-acetylgalactosaminyltransferase
D-galactosyltransferase
N-acetyl-D-galactosamine
D-galactose
Greatest amount of H antigen
O
O > A2 > B > A2B > A1 > A1B
Least amount amount of H antigen
A1B
COMPARISON OF TYPE 1 and TYPE 2 CHAIN:
Link: Beta 1,3
Origin: Plasma
Controlling genes: H, A, B, Se and Lewis
Type 1
COMPARISON OF TYPE 1 and TYPE 2 CHAIN:
Link: Beta 1,4
Origin: Erythrogenic precursors
Controlling genes: H, A, B
Type 2
Subgroups of A was discovered by
Von Dungern ((1911)
Lectin Source of A1
Dolichos biflorus
SUBSGROUP OF A:
Branched A Antigens
2 million A antigens
Positive for Anti-A1
Positive for Anti-A1 Lectin
A1
SUBSGROUP OF A:
Linear A Antigens
500,000 A antigens
Positive for Anti-A1
Negative for Anti-A1 Lectin
A1
