Lewis Blood Group Flashcards
Not appear in Erythrocytes ; must be adsorbed from plasma
Lewis Blood Group
Le genes codes for
L-fucosyltransferase
Le genes adds L-fucose in
Type 1 chain
Le gene must be present to exhibit
Le ^ a
Le and Se gene must be present to exhibit
Le ^ b
ABH, lele, sese
Substance:
Phenotype:
Substance: NONE
Phenotype: ABH Le (a- b-)
ABH, lele, SeSe or Sese
Substance:
Phenotype:
Substance: ABH
Phenotype: ABH Le (a- b-)
ABH, LeLe or lele, sese
Substance:
Phenotype:
Substance: Le^a
Phenotype: ABH Le (a+ b-)
ABH, LeLe or Lele, SeSe or Sese
Substance:
Phenotype:
Substance: Le^a and Le^b
Phenotype: ABH Le (a- b+)
Not synthesized in blood ; antigens are absorbed from plasma
Lewis Antigens
Cord blood and Infants has what Lewis Phenotype
Le (a- b-)
Decrease expression of Lewis antigens is observed in
Pregnant women
IgM
Naturally Occurring
Made by Le (a- b-) individuals
Frequently Encountered in Pregnant Woman
Lewis Antibodies
Most frequently encountered Lewis Antibody
Anti-Le^a
Can react @RT
Can also react @37 deg cel in IAT
Anti-Le^a
