Kell Blood group Flashcards
Predominant Population with:
K - k +
Blacks 96.5
Predominant Population with
K+ k+
Whites 8.8
Predominant Population with
K+ k-
Whites 0.2
- Immunogenic
- Second to D in terms of
Immnogenecity - well developed at birth
Kell antigen
- common antibody encountered in BB
- IgG
- bind complement
- Severe HTR and HDN
Anti-K
Antibodies against Low-frequency Kell antigen
Kp^a
Js^a
Antibodies against HIGH-frequency Kell antigen
k
Kp^b
Js^b
Express weak K antigen
McLeod Phenotype
Causes x-linked Chronic Granulomatous Disease (CGD)
McLeod Phenotype
Kell 1
K
Kell
Kell 2
k
Cellano
Kell 3
Kp^a
Penney
Kell 4
Kp^b
Rautenberg
Kell 6
Js^a
Sutter
Kell 7
Js^b
Matthews
Precursor substance of Kell antigen
Kx
Genes that codes for Kx
X1k
Kx are found on (2)
WBC
RBC
Location by which Kx remained unconverted
WBC
Lack Kx with Abnormal RBC projections (ACANTHOCYTES)
McLeod Phenotype
Lack leukocytic Kx causes CGD
RBC
Condition by which neutrophil cannot kill ingested microorganisms
CGD
k, Kp^b, Js^b can be detected through
Adsorption
Elution
RBC lacks all Kell antigens
Kell null (Ko)