Miscellaneous Gastroenterology Flashcards

1
Q

Features of appendicitis

A

Central pain radiating to RIF
Anorexia
Rovsings sign (press LIF, pain in RIF)
Guarding on abdominal palpation
Rebound tenderness in the RIF (increased pain when suddenly releasing the pressure of deep palpation)
Percussion tenderness (pain and tenderness when percussing the abdomen)
Neutrophil predominant leukocytosis

NB- Rebound tenderness and percussion tenderness suggest peritonitis, potentially indicating a ruptured appendix.

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2
Q

Investigations and management for appendicitis

A

Clinical diagnosis, but USS useful in young females (pelvic organ pathology)
Laparoscopic appendicectomy with prophylactic IV ABX

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3
Q

How to calculate units of alcohol

A

Number of millilitres by the %, then divide by 1000

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4
Q

Alcoholic ketoacidosis

A

Non diabetic euglycaemic form of ketoacidosis (often alcoholics)

Metabolic acidosis with elevated anion gap, ketonaemia, normal or low glucose

Treat (vitamin B1) with infusion of saline and thiamine (always correct thiamine before glucose)

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5
Q

What are carcinoid tumours

A

Cause carcinoid syndrome- typically liver metastases that release serotonin systematically (also lung)- can also release pituitary hormones eg. ACTH

Features- flushing, diarrhoea, bronchospasm, hypotension, valvular stenosis, pellagra

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6
Q

Investigations and management or carcinoid tumours

A

Urinary 5-HIAA

Management- somatostatin analogue eg. Octreotide

NB0 cardiac manifestations: pulmonary stenosis and tricuspid insufficiency

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7
Q

Risk factors for bowel ischaemia

A

Increased age
Emboli- AF, malignancy, infective endocarditis
CVD risk factors
Cocaine

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8
Q

Features of bowel ischaemia

A

Abdominal pain
Rectal bleeding
Diarrhoea
Fever
Bloods- elevated WCC, lactic acidosis

CT- investigation of choice

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9
Q

Acute mesenteric ischameia

A

Sudden onset acute abdominal pain
Out of keeping with physical exam findings
Urgent surgery required

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10
Q

Chronic mesenteric ischaemia

A

Intestinal angina
Colicky, intermittent, abdominal pain

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11
Q

Ischaemic colitis

A

Acute but transient compromise to blood flow in large bowel- inflammation ulceration and haemorrhage
Most likely to occur in splenic flexture
Thumb printing on x ray
Supportive management
Surgery in severe cases

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12
Q

Metoclopramide

A

D2 receptor antagonist

Used in management of nausea, GORD, gastroporeis, migraine

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13
Q

Adverse effects of metoclopramide

A

Extrapyramidal eg, oculogyric crisis, tardive dyskinesia, Parkinsonism
Hyperprolactinameia

Avoid in bowel obstruction, may be helpful in paralytic ileus

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14
Q

Peutz Jeghers syndrome

A

Hamartomatous polyps in small bowel
Pigmented lesions on lips, oral mucosa, face, palms, soles
Intestinal obstruction (intussusception)
GI bleeding

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15
Q

Adverse effects of PPI’s

A

Hyponatraemia, hypomagnesia
Osteoporosis- fracture risk
Colitis
Increased risk of c diff infection

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16
Q

Features of refeeding syndrome

A

Hypophoshphataemia
Hypokalaemia
Hypomagnesia
Abnormal fluid balance

If someone hasn’t eaten for 5 days, feed at no more than 50% of their requirements for 2 days

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17
Q

Small bowel bacterial overgrowth syndrome

A

Diabetes Mellitus and scleroderma

Similar features to IBS

Hydrogen breath test for diagnosis

Correct underlying disorder and rifaximin (ABX)

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18
Q

Spontaneous bacterial peritonitis

A

Usually seen in patients with ascites secondary to liver cirrhosis

Can be asymptomatic so have a low threshold for ascitic fluid culture, Fever, Abdominal pain, Deranged bloods (raised WBC, CRP, creatinine or metabolic acidosis), Ileus, Hypotension

Paracentesis- neutrophils >250, usually E. coli when ascitic fluid is cultured

Give prophylaxis to people who have had this before

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19
Q

Vitamin A

A

Retinol

Deficiency causes nighttime blindness

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20
Q

Vitamin B1

A

Thiamine

Deficiency- WKS, wet beri beri (heart)

Causes of deficiency- alcohol excess, malnutrition

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21
Q

Dry beri beri

A

Peripheral neuropathy

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22
Q

Wet beri beri

A

Dilated cardiomyopathy

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23
Q

Vitamin B3

A

Niacin

Deficiency causes pellagra- dermatitis, diarrhoea, dementia

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24
Q

Vitamin B6

A

Pyridoxine

Peripheral neuropathy and sideroblastic anaemia

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25
Vitamin C
Ascorbic acid Deficiency (scurvy) - gingivitis, loose teeth, poor wound healing, bleeding from gums, haematuria, epistaxis, general malaise, echymosis, easy bruising, Sjogrens, arthralgia
26
Zolinger Ellison syndrome
Syndrome caused by excess gastrin Usually a duodenal or pancreatic tumour MEN1 Diagnosis- fasting gastric levels Features- gastric duodenal ulcers, diarrhoea, malabsorption
27
Ileostomy
Right iliac fossa Spouted Liquid
28
Colostomy
Often LHS Flushed to skin (not spouted) Solid output
29
Loop ileostomy
Used to de function colon following resection eg. Rectal cancer surgery Does not decompress colon Usually right iliac fossa Reversible The bowel is partially opened and folded so that there are two openings on the skin side-by-side, attached in the middle. NB- wouldn't be created after a pancolectomy (as there is nothing to attach the ileum to after reversal has been carried out- only used when there is colon left that can be re-attached after a certain time)
30
End ileostomy
Following complete excision of colon Reversal difficult
31
Loop colostomy
Reversible Serves to defunction and decompress a distal segment of colon in obstructing cancers
32
Features of anal cancer
Perianal pain Perianal bleeding Palpable lesion Faecal incontinence
33
Investigations for anal cancer
DRE, anoscopy with biopsy, check inguinal lymph nodes Imaging Check HIV status
34
Risk factors for an anal fissure
Constipation IBD STI- HIV, syphilis, herpes
35
Features of an anal fissure (fissure in ano)
Painful, bright red rectal bleeding 90% occur on the posterior midline, if they are in alternate location, think of another cause eg, Crohn’s disease
36
Management of an acute anal fissure
Soften stool- dietary advice, bulk forming laxative Lubricants before defeacation Topical anaesthetic or analgesia
37
Management of a chronic anal fissure
Same measures as acute fissure Topical GTN IF GTN doesn’t work after 8 weeks- sphincterectomy or Botox
38
Pruritus ani
Itchy anus
39
Anal fistula
Usually due to a previous anorectal abscess
40
Rectal prolapse
Associated with childbirth and rectal intussception Internal or external
41
Solitary rectal ulcer
Chronic straining and constipation
42
Causes of large bowel obstruction
Tumour Volvulus Diverticula disease Adhesions Hernias Strictures NB- not ileus as there is no obstruction in ileus, just a lack of peristalsis/movement
43
Clinical features of large bowel obstruction-+
Symptoms and signs of underlying cause eg. CRC Absence of flatus and stool Abdominal pain and distension Nausea and vomiting (green bilious vomit) Peritonism if perforation Tinkling” bowel sounds may be heard in early bowel obstruction
44
Investigations for large bowel obstruction
Acute abdomen investigations, A-E assessment etc. Abdominal x ray CT scan
45
Management of large bowel obstruction
NBM, NG tube, IV fluids Conservative management for 72 hours can be trialled if no perforation Surgery (resection etc.) + IV antibiotics
46
Features of a perianal abscess
Pain around the anus, worse on sitting Hardened tissue in the anal region Pus like discharge from anus Long-standing- may have systemic features Associated with crohns, DM, underlying malignancy
47
Treatment of a perianal abscess
Incision and drainage Antibiotics if systemic symptoms
48
Thrombosed haemorrhoids
Significant pain and tender lump Purple, oedematous perianal mass If within 72 hours- excision. Otherwise, stool softeners, ice packs, analgesia
49
Features of a volvulus
Twisting of the colon around itself Constipation Abdominal pain and bloating Nausea and vomiting
50
Management of volvulus
Refer to general surgeons Sigmoid- rigid sigmoidoscopy with rectal tube insertion Caecal- operative (right hemicolectomy sometimes required)
51
Complications of a laparoscopy
Anaesthetic risk Vasovagal (bradycardia) in response to abdominal distension Surgical emphysema Injury to GI tract Injury to blood vessels
52
Management of malignant surgical jaundice
Stent
53
Diagnosing surgical jaundice
Observations and abdominal examination Bloods- FBC UE LFT clotting screen CRP ESR etc. RUQ USS of liver and biliary tree CT abdomen or ERCP/MRCP
54
Melanosis coli
Laxative abuse
55
Medication to avoid in bowel obstruction
Metoclopramide
56
Management of SBP
Take an ascitic culture prior to giving antibiotics Usually treated with an IV cephalosporin such as cefotaxime
57
Hepatorenal syndrome
Hepatorenal syndrome occurs in liver cirrhosis. Hypertension in the portal system leads to dilation of the portal blood vessels, stretched by large amounts of blood pooling there. This leads to a loss of blood volume in other areas of the circulation, including the kidneys. This leads hypotension in the kidney and activation of the renin-angiotensin system. This causes renal vasoconstriction, which combined with low circulation volume leads to starvation of blood to the kidney. This leads to rapid deteriorating kidney function.
58
What is ileus
a condition affecting the small bowel, where the normal peristalsis that pushes the contents along the length of the intestines, temporarily stops. It may be referred to as paralytic ileus or adynamic ileus.
59
What is ileus
a condition affecting the small bowel, where the normal peristalsis that pushes the contents along the length of the intestines, temporarily stops. It may be referred to as paralytic ileus or adynamic ileus.
60
Causes of ileus
Injury to the bowel Handling of the bowel during surgery Inflammation or infection in, or nearby, the bowel (e.g., peritonitis, appendicitis, pancreatitis or pneumonia) Electrolyte imbalance (e.g., hypokalaemia or hyponatraemia)
61
Features of ileus
Akin to obstruction, namely; Vomiting (particularly green bilious vomiting) Abdominal distention Diffuse abdominal pain Absolute constipation and lack of flatulence Absent bowel sounds (as opposed to the “tinkling” bowel sounds of mechanical obstruction)
62
Management of ileus
Supportive- will resolve on its own eg. Nil by mouth or limited sips of water NG tube if vomiting IV fluids to prevent dehydration and correct the electrolyte imbalances Mobilisation to helps stimulate peristalsis Total parenteral nutrition (TPN) may be required whilst waiting for the bowel to regain function
63
What is a volvulus?
a condition where the bowel twists around itself and the mesentery that it is attached to (either sigmoid or caecal- X ray shows either coffee bean or foetus sign)
64
Volvulus risk factors
Neuropsychiatric disorders (e.g., Parkinson’s) Nursing home residents Chronic constipation High fibre diet Pregnancy Adhesions
65
Features of a volvulus
Akin to bowel obstruction, namely; Vomiting (particularly green bilious vomiting) Abdominal distention Diffuse abdominal pain Absolute constipation and lack of flatulence
66
Management of a volvulus
Conservative- same as obstruction eg. fluids, analgesia, NBM, NG tube etc. Surgical- endoscopic resection for sigmoid volvulus (no peritonitis), or laparotomy/ colectomy etc.
67
Complications of stomas
Psycho-social impact Local skin irritation Parastomal hernia Loss of bowel length leading to high output, dehydration and malnutrition Constipation (colostomies) Stenosis Obstruction Retraction (sinking into the skin) Prolapse (telescoping of bowel through hernia site) Bleeding Granulomas causing raised red lumps around the stoma
68
Cholangiocarcinoma
Cancer arising from the bile ducts. Key risk factors include; Primary sclerosing cholangitis Liver flukes (a parasitic infection)
69
Features of cholangiocarcinoma
Obstructive jaundice Unexplained weight loss Right upper quadrant pain Palpable gallbladder (swelling due to an obstruction in the duct distal to the gallbladder) Hepatomegaly
70
Most appropriate analgesia following an abdominoperineal resection
Epidural
71
Investigation of choice in severe colitis
Flexible sigmoidoscopy, not colonoscopy
72
Differentials for an abdominal mass
ovarian pathology – ovarian cyst/benign tumour, ovarian cancer tubal pathology – tubo-ovarian abscess, tubal malignancy (treat as ovarian) uterine pathology – pregnancy, fibroids/benign tumour, uterine cancer urological pathology – distended bladder, pelvic kidney, transplanted kidney GI pathology – the 6 Fs: fat, fluid, flatus, faeces, fetus, filthy big tumour other abdominal pathology – primary peritoneal cancer, retroperitoneal sarcoma.
73
Hiatus hernia
sliding: accounts for 95% of hiatus hernias, the gastroesophageal junction moves above the diaphragm rolling (paraoesophageal): the gastroesophageal junctions remains below the diaphragm but a separate part of the stomach herniates through the oesophageal hiatus Features heartburn dysphagia regurgitation chest pain Investigation barium swallow is the most sensitive test given the nature of the symptoms many patients have an endoscopy first-line, with a hiatus hernia being found incidentally Management -all patients benefit from conservative management e.g. weight loss -medical management: proton pump inhibitor therapy -surgical management: only really has a role in symptomatic paraesophageal hernias
74
Femoral Hernia
inferolateral to the pubic tubercle cough impulse is often absent More common in women Incarceration- where the herniated tissue cannot be reduced Strangulation- high risk in femoral hernias (repair is a necessity, no hernia belts)
75
Inguinal hernia
superior and medial to the pubic tubercle disappears on pressure or when the patient lies down treat medically fit patients even if they are asymptomatic(hernia belt if not fit for surgery) -unilateral inguinal hernias are generally repaired with an open approach -bilateral and recurrent inguinal hernias are generally repaired laparoscopically anatomical differences between indirect (hernia through the inguinal canal) and direct hernias (through the posterior wall of the inguinal canal) following an open repair patients return to non-manual work after 2-3 weeks and following laparoscopic repair after 1-2 weeks NB- indirect inguinal hernias may occur in infants (others are more common in adults) NB- congenital inguinal hernias should be surgically repaired soon after diagnosis as at risk of incarceration NB- indirect inguinal hernias can be in the scrotum (NOT A SCROTAL HERNIA- ITS indirect INGUINAL)
76
Complications of an ileostomy
May develop significant volume depletion, electrolyte and acid-base disturbances (metabolic acidosis) if the ileostomy output increases or if dietary intake is disrupted or altered
77
Investigation of choice for SBO
CT abdomen
78
Spigelian hernia
seen lateral to the umbilicus