Miscellaneous Cardiology Flashcards

1
Q

Right to left shunt

A

Blood flows from right side of heart (deoxygenated) into the left sided of the heart without passing through lungs to pick up oxygen (cyanosis).

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2
Q

Causes of a right to left shunt (cyanosis heart disease)

A

VSD
ASD
Patent ductus arteriosus
Transposition of the great arteries

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3
Q

Why are people with ASD VSD PDA usually not cyanotic?

A

Left sided heart pressure greater than right, so prevents the shunt

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4
Q

Eisenmenger syndrome

A

When pulmonary pressure (hypertension) is greater than systemic pressure so blood flows from the right to left shunt causing cyanosis

NB- treated by heart-lung transplant

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5
Q

Complications of congenital heart disease

A

Heart failure
Arrhythmias
Endocarditis
Stroke
PE
Eisenmenger syndrome

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6
Q

Adult presentation of septal defects

A

Dyspnoea (pulmonary HTN, right sided heart failure)
Stroke (due to VTE)
AF

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7
Q

What is coarctation if aorta associated with

A

Turners syndrome

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8
Q

Conditions associated with VSD

A

Down’s syndrome
Turners syndrome

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9
Q

Adults signs of coarctation of the aorta

A

HTN
Murmur
Underdeveloped left arm
Underdeveloped left leg

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10
Q

Features of TOF

A

Cyanosis
Right to left shunt
Murmur
Right sided aortic arch
Boot shaped heart

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11
Q

Management of TOF

A

Surgical repair in 2 parts
Cyanotic episodes (Tet spells) helped by beta blockers

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12
Q

Most common cyanotic heart disease

A

At birth- transposition of the great arteries
Overall (1-2 months)- TOF

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13
Q

What is ebsteins anomaly

A

Low insertion of tricuspid valve- large atrium and small ventricle (atrialisation of the right ventricle)

Can be caused by lithium in utero

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14
Q

Associations of ebsteins anomaly

A

PFO or ASD
WPW syndrome

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15
Q

Clinical features of Ebsteins anomaly

A

Cyanosis
Prominent a wave in JVP
Hepatomegaly
Tricuspid regurgitation
RBBB

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16
Q

Pathophysiology of HOCM

A

Autosomal dominant
Defects in myosin genes
Diastolic dysfunction
Myofibrilar hypetrophy with chaotic myocytes (disarray) and fibrosis on biopsy

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17
Q

Features of HOCM

A

Often asymptomatic
Exertional dyspnoea
Syncope following exercise
Sudden death (ventricular arrhythmia)
Jerky pulse, large a waves
Systolic murmur
Bisferens pulse (2 S1 waves)

NB- can develop into Heart failure with preserved ejection fraction (HF-pEF)

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18
Q

HOCM associations

A

Friedrichs ataxia (neuro degenerative movement disorder)
WPW syndrome

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19
Q

HOCM Findings

A

Echo- LVH, MR

ECG- LVH, AF, deep Q waves, non specific ST segment and T wave abnormalities

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20
Q

What is Takotsubo cardiomyopathy

A

Non ischaemic cardiomyopathy associated with transient, apical ballooning of myocardium, associated with stress

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21
Q

Features of Takotsubo cardiomyopathy

A

Chest pain
Heart failure
ST elevation
Normal coronary angiogram

NB- treatment is supportive

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22
Q

Dilated cardiomyopathy

A

Most common type
Systolic dysfunction
Eccentric hypertrophy

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23
Q

Causes of dilated cardiomyopathy

A

Idiopathic (most common)
Myocarditis (cockasackiem Chaga)
IHD
Peripartum
HTN
Iatrogenic (doxorubicin)
Substance misuse eg. Alcohol and cocaine
Genetics eg. DMD
Infiltrative eg. Haemachromatosis or sarcoidosis
Wet beriberi (thiamine deficiency)

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24
Q

Features of dilated cardiomyopathy

A

Heart failure
Murmur
S3
Balloon appearance of heart on CXR

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25
Restrictive cardiomyopathy
Amyloidosis Post radiotherapy Loefflers endocarditis Beriberi
26
HOCM Management
ABCDE Amiodarone Beta blocker or verapamil for Sx Cardiovertee defibrillator Dual chamber pacemaker Endocarditis prophylaxis (not always) Avoid- nitrates, ACE-I, inotropes
27
INR target range for mechanical valves
2.5-3.5
28
Complications of mechanical heart valves
Thrombus Infective endocarditis (staphylococcus) Haemolysis (anaemia)
29
Indications for a pacemaker
Symptomatic bradycardia Mobitz type 2 AV block Third degree heart block Severe heart failure HOCM (ICD)
30
ECG with a pacemaker
Sharp vertical line before all leads on the trace
31
Sing,e chamber
A line before either the P or the QRS complex
32
Dual chamber pacemaker
A line before either the P or the QRS
33
Target INR for AF
2-3
34
Reversing warfarin
Vitamin K and PCC
35
Reversing NOACs
Apixaban/rivaroxaban- andexanet alpha Dabigatran- idarucizumab
36
Outcome of chadvasc score
0- no anticoagulation 1- consider anticoagulation 2- offer anticoagulation
37
Tests before starting amiodarone
TFT LFT UE CXR
38
Arrhythmogenic right ventricular cardiomyopathy
a form of inherited cardiovascular disease which may present with syncope or sudden cardiac death.
39
Investigations for ARVC
ECG abnormalities in V1-3, typically T wave inversion. An epsilon wave is found in about 50% of those with ARV - this is best described as a terminal notch in the QRS complex echo changes are often subtle in the early stages but may show an enlarged, hypokinetic right ventricle with a thin free wall magnetic resonance imaging is useful to show fibrofatty tissue
40
Management of ARVC
drugs: sotalol is the most widely used antiarrhythmic catheter ablation to prevent ventricular tachycardia implantable cardioverter-defibrillator
41
Amiodarone
Uses- ALS and VTach MOA- blocking potassium channels SE's- hypo and hyperthyroid, fibrosis (lung and liver), neuropathy, grey skin, increased QT interval
42
Adenosine
Uses- SVT MOA- causes transient heart block in the AV node, and is an agonist of the A1 receptor in the atrioventricular node SE's- avoid in asthmatics, chest pain, bronchospasm transient flushing (sense of heart stop & impending doom), can enhance conduction down accessory pathways, resulting in increased ventricular rate (e.g. WPW syndrome)
43
Atropine
Bradycardia SE's- anticholinergic
44
Causes of acyanotic heart disease
VSD (more common) ASD (most common new diagnosis in adults- present later) PDA Coarctation of aorta Aortic valve stenosis
45
Causes of cyanotic heart disease
Teratology of Fallot Transposition of the great arteries (TGA) Tricuspid atresia
46
Characteristics of Teratology of Fallot
VSD RVH RV outflow tract obstruction, pulmonary stenosis Overriding aorta
47
Features of teratology of Fallot
Most common cause of congenital cyanotic heart disease, although as it presents at 1-2 months, TGA is more common at birth Cyanosis Right to left shunt Systolic murmur Right sided aortic arch (25% patients) Boot shaped heart X ray, ECG- RVH Surgical repair (2 parts, beta blockers)
48
Causes of an S3 heart sound
caused by diastolic filling of the ventricle considered normal if < 30 years old (may persist in women up to 50 years old) heard in left ventricular failure (e.g. dilated cardiomyopathy), constrictive pericarditis (called a pericardial knock) and mitral regurgitation
49
Constrictive pericarditis
Causes- recent cardiac surgery, any cause of pericarditis, particularly TB Features; dyspnoea right heart failure: elevated JVP, ascites, oedema, hepatomegaly JVP shows prominent x and y descent pericardial knock - loud S3 Kussmaul's sign is positive (a paradoxical rise in JVP during inspiration) NB- pericardial calcification on CXR
50
Constrictive pericarditis vs cardiac tamponade
JVP: tamponade, only X (tamponade tampaX), pericarditis, X & Y Pulsus parodoxus (fall in BP >10 during inspiration): tamponade, present, pericarditis, absent Kussmaul's sign: tamponade, rare, pericarditis, present CXR calcification- constrictive pericarditis
51
ECG Normal Variants
Normal variants on the ECG: -Sinus arrhythmia -Right axis deviation (tall and thin individuals) -Left axis deviation (short, obese individuals) -Partial right bundle branch block Athletes often have a high vagal tone which results in additional normal variants: -Sinus bradycardia -1st degree atrioventricular block -Wenckebach phenomenon (2nd degree atrioventricular block Mobitz type 1) -Junctional escape rhythm NB- LBBB is never a normal variant
52
Heart failure with preserved ejection fraction (HF-pEF)
No systolic (outflow) problem, but a diastolic (backlog) problem
53
Heart failure with reduced ejection fraction (HF-pEF)
Both diastolic and systolic dysfunction
54
Options for aortic valve replacement
surgical AVR is the treatment of choice for young, low/medium operative risk patients. Cardiovascular disease may coexist. For this reason, an angiogram is often done prior to surgery so that the procedures can be combined transcatheter AVR (TAVR) is used for patients with a high operative risk balloon valvuloplasty may be used in children with no aortic valve calcification in adults limited to patients with critical aortic stenosis who are not fit for valve replacement
55
fusion and capture beats
unsure
56
Miscellaneous cardiology
Cardiogenic Shock: e.g. MI, valve abnormality increased SVR (vasoconstriction in response to low BP) increased HR (sympathetic response) decreased cardiac output decreased blood pressure Hypovolaemic shock: blood volume depletion e.g. haemorrhage, vomiting, diarrhoea, dehydration, third-space losses during major operations increased SVR increased HR decreased cardiac output decreased blood pressure Septic shock: occurs when the peripheral vascular dilatation causes a fall in SVR similar response may occur in anaphylactic shock, neurogenic shock reduced SVR increased HR normal/increased cardiac output decreased blood pressure
57
Digoxin
used for rate control in the management of atrial fibrillation. As it has positive inotropic properties it is sometimes used for improving symptoms (but not mortality) in patients with heart failure MOA; decreases conduction through the atrioventricular node which slows the ventricular rate in atrial fibrillation and flutter increases the force of cardiac muscle contraction due to inhibition of the Na+/K+ ATPase pump. Also stimulates vagus nerve Monitoring; digoxin level is not monitored routinely, except in suspected toxicity if toxicity is suspected, digoxin concentrations should be measured within 8 to 12 hours of the last dose
58
Digoxin Toxicity
Toxicity; Toxicity may occur even when the concentration is within the therapeutic range. Features; generally unwell, lethargy, nausea & vomiting, anorexia, confusion, yellow-green vision arrhythmias (e.g. AV block, bradycardia) gynaecomastia Precipitating factors classically: hypokalaemia digoxin normally binds to the ATPase pump on the same site as potassium. Hypokalaemia → digoxin more easily bind to the ATPase pump → increased inhibitory effects increasing age renal failure myocardial ischaemia hypomagnesaemia, hypercalcaemia, hypernatraemia, acidosis hypoalbuminaemia hypothermia hypothyroidism drugs: amiodarone, quinidine, verapamil, diltiazem, spironolactone (competes for secretion in distal convoluted tubule therefore reduce excretion), ciclosporin. Also drugs which cause hypokalaemia e.g. thiazides and loop diuretics Management; Digibind correct arrhythmias monitor potassium
59
AF and BBB
Atrial fibrillation with bundle branch block is the most likely cause of an irregular broad complex tachycardia in a stable patient
60
Potential risk of asystole
The following are risk factors for asystole. Even if there is a satisfactory response to atropine specialist help is indicated to consider the need for transvenous pacing: complete heart block with broad complex QRS recent asystole Mobitz type II AV block ventricular pause > 3 seconds
61
Shock
5 types Cardiogenic Hypovolaemic Neurogenic Anaphylactic Septic All cause hypotension and tachycardia, except neurogenic which causes hypotension and bradycardia C/H shock cause increased SR A/S shock cause decreased SR