Miscellaneous Flashcards by Eric Sun

What are the Gq coupled receptors?

HAVe 1 M&amp;M
H1
alpha1
V1
M1 and M3

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What are the 2 receptors on uterus, and what do they do?

Alpha 1—>contraction

Beta 2—>relaxation

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MOA of amphetamine/cocaine/MDMA/TCA?

Amp—>increase release of all 3 (NE/DA/5HT)
MDMA—>increase release of 5HT (happy!)
Cocaine—>block reuptake of NE/DA
TCA—>block reuptake of NE/5HT

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Side effects of digoxin?

M agonist including blurry yellow vision (Van Gogh?)

Arrhythmia

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Which 2 antibiotics should not be given to children and why?

Fluoroquinolone and doxycycline

Because of side effects

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What is buprenorphine and what is it used for?

Partial mu agonist

Combine with naloxone for heroin addiction

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Which antidepressant drug work like cocaine? and what is it used?

Bupropion

Alternative to SSRI since no sexual dysfunction

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MOA of trazodone? usage?

Block 5HT2a/alpha 1/H1

Insomnia/high dose for antidepressant

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Which antidepressant is sometimes used for pt who needs to gain weight? and which SSRI is the only approved drug for bulimia?

Mirtazapine

Fluoxetine

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Carve my heart in bits?

Common beta blockers used for heart failure

Carvedilol/metoprolol/bisoprolol

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Which muscarinic toxicity caused by AChE inhibitor can not be reversed with atropine?

Muscle paralysis—>since it is mediated by Nm receptor and atropine only blocks M

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How do “zosin” treat BPH?

Decrease tone of urinary sphincter

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Difference between efficacy and potency?

Efficacy—>max effect a drug can produce regardless of dose

Potency—>amount of drug needed for a given effect (effect must be the same)

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Toxicity of theophylline?

Tremor and seizure

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Loop and thiazide would increase which hormone?

Aldosterone—>and that’s why you get hypokalemia and alkalosis with them

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Dont use class 4 antiarrhythmia in what pts

HF—>it makes it worse

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Effect of increasing atropine dosage?

decrease secretion—>mydriasis and cycloplegia—>hyperthermia—>tachy—>urinary retention—>hallucination

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What would cause accommodation of near vision?

M agonist

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Stimulate what receptor would cause prostate contraction?

Alpha 1

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Epi can be used for ___ but NE can not be used for

Asthma (because of beta 2)

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MOA of yohimbine? usage?

Alpha 2 antagonist—>postural HoTN and male impotence

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What kind of beta blockers block renin release?

Beta 1 selective

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Which 2 beta blockers have intrinsic sumpathomimetic activities (partial agonist)?

Pindolol and acebutolol

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Which beta blocker cause the highest degree of sedation?

Propranolol

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How does closed angle glaucoma occur?

Blockade of canal of schlemm

Nesiritide? used for?

BNP--->increase cGMP--->vasodilate | Acute decompensated HF

Can dobutamine be used in chronic CHF?

What metabolic disease can chronic steroid usage cause?

What are doxepin and meclizine?

Doxepin--->TCA | Meclizine---->anti histamine/used for antiemetic for pregos

Dont use ___ for angina prophylaxis for DM pt

Beta blockers

Which lipid lowering drug shouldnt you give if a pt has liver disease? what is another name for it?

Niacin | Nicotinic acid

Which lipid lowering agent is a teratogen?

Statins

TCA would decrease the efficacy of which other antiHTN drug?

Guanethdine--->it uses Uptake 1 for transportation--->TCA blocks reuptake

What electrolyte abnormality worsen Li+ toxicity?

Hyponatremia

What enzyme does carbidopa inhibit?

dopa decarboxylase

Is valproic acid a CYP450 inhibitor or inducer?

Inhibitor

How does opioid affect the gallbladder?

Causes biliary colic (contraction of gallbladder)

What side effects would opioid user not be able to develop tolerance to

Constipation and miosis

What can be used for cocaine and amphetamine withdraw?

TCA (counter depression)

Which 2 doxycycline are excreted in feces?

Mino and doxycycline

Which macrolide can you use for pregnant women?

Erythromycin

Side effect of foscarnet? Ribavirin?

Electrolyte abnormalities--->hypokalemia/hypocalemia | Teratogen

MOA of ergotamine?

Alpha 1 and 5HT2 partial agonist

Carbamazapine and phenytoin both cause?

Aplastic anemia

If the pt is allergic to bactrium, which DM drug cant you give?

Sulfonylurea (sulfa allergy)

Which migraine drug can cause HTN crisis?

Triptans

What can diazoxide used for?

HTN crisis and hyperinsulinism

How does steroid cause osteoporosis?

Increase bone resorption and decrease bone formation | Decrease Ca absorption and increase Ca excretion

Which macrolide does not have CYP450 inhibition effect?

Azithromycin

What electrolyte abnormalities do succinycholine cause? and should be avoided to use in ___ pt

Hyper Ca and hyper K | Burn

Side effect of sirolimus?

Hyperlipidemia/pancytopenia/NOT renal toxic

If a pt is allergic to bactrim, what diuretics cannot be given? and what else?

Loop/thiazide/carbonic anhydrase inhibitor besides erthranyic acid Celeoxib

What are the 2 special beta blockers? usage?

Carvedilol and labetalol | HTN crisis and pheochromocytoma

Which 2 beta blockers should not be given to angina pt?

Pindolol and acebutolol

What does demeclocycline cause?

nephrogenic DI

Which NSAIDs shouldnt you give to a gouty pt?

Aspirin

DOC for acute gout attack?

Indomethacin

What 2 drugs displace warfarin?

Aspirin and phenytoin

Which anticoagulant is used for pregos?

Xabans

Streptokinase is used with __ to reduce reinfarction and does not cause much more bleeding

Aspirin

cAMP increase or reduce platelet aggregation?

Decrease

Which 2 DM drug increase peripheral glucose uptake?

Metformin and glitazones

Take warfarin will increase or decrease your INR?

Increase (INR is how long it takes for your blood to clot)

Anti CCP antibodies?

Which diuretic cannot be used for crush injury pt?

K sparing diuretics Crush injury---->myeglobuinemia-->high potassium K sparing diuretics cause high potassium--->combination is bad

Which anticoagulant has neutropenia as side effect?

Ticlopidine

Affect of anabolic steroids?

Increase EPO--->increase Hb and RBCs

Uterine bleed and acne can be treated with?

estrogen replacement

Which progesterone analog is not androgenic and anti estrogenic

Desogestrel

Effect of iodide on hyperthyroidism?

Inhibit T4 release from the thyroid

What is the synthetic version of somatropin?

Somatrem

What drugs are used to treat steroid induced osteoporosis?

Dronates

What does mycophenolate inhibit?

Inosine monophosphate dehydrogenase

Dronabinol?

Increase appetite during chemo therapy

Drugs used for stable angina? can you used beta blockers for vasospasm?

Nitrates/Ca channel blockers/beta blockers | No

Drugs that decrease mortality for stable angina pt

Beta blocker/nitroglycerin/aspirin

DOC for raynaud?

Nifedipine

Ranolazine? side effect?

Block Na current flow in the heart | Torsades

What do PDE3 and 5 break down?

PDE3--->cAMP cAMP--->phosphorylation of MLCK--->SM relaxation PDE5--->cGMP cGMP--->PKG--->dephosphorylation of MLC--->SM relaxation