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Unit 4 > Miscellaneous > Flashcards

Miscellaneous Flashcards

1
Q

What are the Gq coupled receptors?

A 
HAVe 1 M&M
H1
alpha1
V1
M1 and M3
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2
Q

What are the 2 receptors on uterus, and what do they do?

A

Alpha 1—>contraction

Beta 2—>relaxation

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3
Q

MOA of amphetamine/cocaine/MDMA/TCA?

A

Amp—>increase release of all 3 (NE/DA/5HT)
MDMA—>increase release of 5HT (happy!)
Cocaine—>block reuptake of NE/DA
TCA—>block reuptake of NE/5HT

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4
Q

Side effects of digoxin?

A

M agonist including blurry yellow vision (Van Gogh?)

Arrhythmia

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5
Q

Which 2 antibiotics should not be given to children and why?

A

Fluoroquinolone and doxycycline

Because of side effects

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6
Q

What is buprenorphine and what is it used for?

A

Partial mu agonist

Combine with naloxone for heroin addiction

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7
Q

Which antidepressant drug work like cocaine? and what is it used?

A

Bupropion

Alternative to SSRI since no sexual dysfunction

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8
Q

MOA of trazodone? usage?

A

Block 5HT2a/alpha 1/H1

Insomnia/high dose for antidepressant

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9
Q

Which antidepressant is sometimes used for pt who needs to gain weight? and which SSRI is the only approved drug for bulimia?

A

Mirtazapine

Fluoxetine

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10
Q

Carve my heart in bits?

A

Common beta blockers used for heart failure

Carvedilol/metoprolol/bisoprolol

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11
Q

Which muscarinic toxicity caused by AChE inhibitor can not be reversed with atropine?

A

Muscle paralysis—>since it is mediated by Nm receptor and atropine only blocks M

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12
Q

How do “zosin” treat BPH?

A

Decrease tone of urinary sphincter

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13
Q

Difference between efficacy and potency?

A

Efficacy—>max effect a drug can produce regardless of dose

Potency—>amount of drug needed for a given effect (effect must be the same)

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14
Q

Toxicity of theophylline?

A

Tremor and seizure

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15
Q

Loop and thiazide would increase which hormone?

A

Aldosterone—>and that’s why you get hypokalemia and alkalosis with them

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16
Q

Dont use class 4 antiarrhythmia in what pts

A

HF—>it makes it worse

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17
Q

Effect of increasing atropine dosage?

A

decrease secretion—>mydriasis and cycloplegia—>hyperthermia—>tachy—>urinary retention—>hallucination

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18
Q

What would cause accommodation of near vision?

A

M agonist

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19
Q

Stimulate what receptor would cause prostate contraction?

A

Alpha 1

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20
Q

Epi can be used for ___ but NE can not be used for

A

Asthma (because of beta 2)

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21
Q

MOA of yohimbine? usage?

A

Alpha 2 antagonist—>postural HoTN and male impotence

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22
Q

What kind of beta blockers block renin release?

A

Beta 1 selective

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23
Q

Which 2 beta blockers have intrinsic sumpathomimetic activities (partial agonist)?

A

Pindolol and acebutolol

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24
Q

Which beta blocker cause the highest degree of sedation?

A

Propranolol

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25
Q

How does closed angle glaucoma occur?

A

Blockade of canal of schlemm

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26
Q

Nesiritide? used for?

A

BNP—>increase cGMP—>vasodilate

Acute decompensated HF

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27
Q

Can dobutamine be used in chronic CHF?

A

No

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28
Q

What metabolic disease can chronic steroid usage cause?

A

DM

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29
Q

What are doxepin and meclizine?

A

Doxepin—>TCA

Meclizine—->anti histamine/used for antiemetic for pregos

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30
Q

Dont use ___ for angina prophylaxis for DM pt

A

Beta blockers

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31
Q

Which lipid lowering drug shouldnt you give if a pt has liver disease? what is another name for it?

A

Niacin

Nicotinic acid

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32
Q

Which lipid lowering agent is a teratogen?

33
Q

TCA would decrease the efficacy of which other antiHTN drug?

A

Guanethdine—>it uses Uptake 1 for transportation—>TCA blocks reuptake

34
Q

What electrolyte abnormality worsen Li+ toxicity?

A

Hyponatremia

35
Q

What enzyme does carbidopa inhibit?

A

dopa decarboxylase

36
Q

Is valproic acid a CYP450 inhibitor or inducer?

37
Q

How does opioid affect the gallbladder?

A

Causes biliary colic (contraction of gallbladder)

38
Q

What side effects would opioid user not be able to develop tolerance to

A

Constipation and miosis

39
Q

What can be used for cocaine and amphetamine withdraw?

A

TCA (counter depression)

40
Q

Which 2 doxycycline are excreted in feces?

A

Mino and doxycycline

41
Q

Which macrolide can you use for pregnant women?

A

Erythromycin

42
Q

Side effect of foscarnet? Ribavirin?

A

Electrolyte abnormalities—>hypokalemia/hypocalemia

Teratogen

43
Q

MOA of ergotamine?

A

Alpha 1 and 5HT2 partial agonist

44
Q

Carbamazapine and phenytoin both cause?

A

Aplastic anemia

45
Q

If the pt is allergic to bactrium, which DM drug cant you give?

A

Sulfonylurea (sulfa allergy)

46
Q

Which migraine drug can cause HTN crisis?

47
Q

What can diazoxide used for?

A

HTN crisis and hyperinsulinism

48
Q

How does steroid cause osteoporosis?

A

Increase bone resorption and decrease bone formation

Decrease Ca absorption and increase Ca excretion

49
Q

Which macrolide does not have CYP450 inhibition effect?

A

Azithromycin

50
Q

What electrolyte abnormalities do succinycholine cause? and should be avoided to use in ___ pt

A

Hyper Ca and hyper K

Burn

51
Q

Side effect of sirolimus?

A

Hyperlipidemia/pancytopenia/NOT renal toxic

52
Q

If a pt is allergic to bactrim, what diuretics cannot be given? and what else?

A

Loop/thiazide/carbonic anhydrase inhibitor besides erthranyic acid
Celeoxib

53
Q

What are the 2 special beta blockers? usage?

A

Carvedilol and labetalol

HTN crisis and pheochromocytoma

54
Q

Which 2 beta blockers should not be given to angina pt?

A

Pindolol and acebutolol

55
Q

What does demeclocycline cause?

A

nephrogenic DI

56
Q

Which NSAIDs shouldnt you give to a gouty pt?

57
Q

DOC for acute gout attack?

A

Indomethacin

58
Q

What 2 drugs displace warfarin?

A

Aspirin and phenytoin

59
Q

Which anticoagulant is used for pregos?

60
Q

Streptokinase is used with __ to reduce reinfarction and does not cause much more bleeding

61
Q

cAMP increase or reduce platelet aggregation?

62
Q

Which 2 DM drug increase peripheral glucose uptake?

A

Metformin and glitazones

63
Q

Take warfarin will increase or decrease your INR?

A

Increase (INR is how long it takes for your blood to clot)

64
Q

Anti CCP antibodies?

65
Q

Which diuretic cannot be used for crush injury pt?

A

K sparing diuretics
Crush injury—->myeglobuinemia–>high potassium
K sparing diuretics cause high potassium—>combination is bad

66
Q

Which anticoagulant has neutropenia as side effect?

A

Ticlopidine

67
Q

Affect of anabolic steroids?

A

Increase EPO—>increase Hb and RBCs

68
Q

Uterine bleed and acne can be treated with?

A

estrogen replacement

69
Q

Which progesterone analog is not androgenic and anti estrogenic

A

Desogestrel

70
Q

Effect of iodide on hyperthyroidism?

A

Inhibit T4 release from the thyroid

71
Q

What is the synthetic version of somatropin?

72
Q

What drugs are used to treat steroid induced osteoporosis?

73
Q

What does mycophenolate inhibit?

A

Inosine monophosphate dehydrogenase

74
Q

Dronabinol?

A

Increase appetite during chemo therapy

75
Q

Drugs used for stable angina? can you used beta blockers for vasospasm?

A

Nitrates/Ca channel blockers/beta blockers

No

76
Q

Drugs that decrease mortality for stable angina pt

A

Beta blocker/nitroglycerin/aspirin

77
Q

DOC for raynaud?

A

Nifedipine

78
Q

Ranolazine? side effect?

A

Block Na current flow in the heart

Torsades

79
Q

What do PDE3 and 5 break down?

A

PDE3—>cAMP
cAMP—>phosphorylation of MLCK—>SM relaxation
PDE5—>cGMP
cGMP—>PKG—>dephosphorylation of MLC—>SM relaxation

Unit 4 (28 decks)

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