FA Flashcards
MOA of memantine and what is it for?
NMDA blocker/Alzheimer’s
MOA of cabergoline and what is it for?
D agonist like bromocriptine/hyperprolactinemia
Histology of hyperacute/acute/chronic transplant rejection>
Hyperacute—>thrombosis/DIC/vascular spasm
Acute—>vasculitis/lymphocyte infiltrate
Chronic—>fibrosis—>ischemia
Most overdose of what drug causes death in US?
Opioid
HoTN/Tachy/decrease RA pressure
Septic shock (fever might not be there if the pt is either old or immunocompromised)
C3a effect
Histamine release
Most common congenital heart defect
Bicuspid aortic valve
See a pt with an autoimmune disease
Think the possibility of having other autoimmune disease
Decrease bicarb comes with
Increase chloride
glutamate is excitatory or inhibitory?
Excitatory
Tetrabenazine
Huntington’s (chlorea)/like reserpine
Milrinone MOA and effect
PDE3 inhibitor/increase contractility and vasodilate
Ranolazine
Decrease O2 consumption/angina
Adenosine
Increase K out of cell—>hyperpolarization
Terminate SVT
carbamazapine cause?
Aplastic anemia
Benzo used for short term anxiety
Lorazepam
Most common cause of death in DM pt
Cardiovascular disease
Coarctation of aorta associated with?
Cerebral hemorrhage (berry aneurysm)
See kid with viral infection (or adult)
think subsequent autoimmune disease like ITP
What is on chromosome 14
Ig heavy chain
Bortezomib
Proteasome inhibitor/Multiple myeloma
Cilostazol/dipyridamole
PDE3 inhibitors
Intermitten claudication/coronary vasodilation
Cell mediated vs. humoral \
Cell mediated—>macrophages (intracellular)
Humoral—>antibody/complement (extracellular)
Mu receptor MOA
Increase K efflux—>hyperpolarize
Rituximab
Anti CD20/anti B cell
Side effect of imatinib
Fluid retention
Trastuzumab
against HER2/cardiotoxicity
Causes of PCOS
Insulin resistance
Theca lutein cyst
Choriocarcinoma/moles
Ovarian tumor with fallopian tube epithelium
Serous cystadenoma
Ovarian tumor that grow in follicles and gland like with fluid in the middle
Granulosa cells (Call-Exner bodies)
Increase in placenta alka phos/fried eggs appearance
Seminoma
Increase AFP, what tumor
Yolk sac tumor
Period pain/heavy bleeding/uniformly enlarged uterus
Adenomyosis
endometrial mass with whorled pattern/sensitive to hormone/bleeding lead to iron deficiency anemia/equivalent in ovary?
Leiomyoma (endometrium)
Fibroma
Danazol
Androgen analog—>decrease FSH/LH—>endometrosis
Breast tumor with lymphocytic infiltrate
Medullary carcinoma
Peau d’orange
Inflammatory breast cancer—>block lymphatic drainage
Grandular/papillary mass in male testis/hemorrhagic
Embryonal
Testistical mass/gynecomastia
Leydig cell tumor
Thoracic aortic aneurysm
Cystic medial degeneration
Cushing triad
HTN/bradycardia/low RR—>increase ICP
Terbutaline
Beta 2 agonist—>relax uterus
Methadone
Full mu agonist/long half life
Immune complex/transmural inflammation/associated with hep B/livdo reticularis what kind of vasculitis?
Polyarteritis nodosa (medium size vessels)
associated with antibiotics, what kind of vasculitis?
Microscopic polyangitis
Essential tremor treat with
beta blocker
Chronic gastritis histology
lymphoid aggregates/atrophy
Menetrier disease
Muscosal cell hyperplasia (brain gyri)—>protein loss/decrease gastric acid
Pt with long term H.pylori infection came in complained of early satiety and weight lost
Intestinal gastric adenocarcinoma
ZE syndrome give rise to ___ ulcer
duodenal ulcer
Anterior/posterior ulcer
Anterior—>perforate
Posterior—>hemorrhage
anti endomysial
Celiac
decrease duodenal pH/fecal elastase
pancreatic insufficiency
Diverticuli MOA
Pulsion—>constipation (false)
Inferior phargyneal constrictor
Killian triangle—>zenker
Hirschsprung mutation
RET
Kids with viral infection, then GI problem
Appendicitis/intussusception
Postprandial pain
Chronic mesenteric ischemia
CEA
colon cancer marker
Fibrosis/regenerative nodule
Cirrhosis
shrunken liver
alcoholic cirrhosis
Rifaximin
treat hepatic encephalopathy
elevated AFP in GI, MC metastisize site
hepatocellular carcinoma/lung
Granulomatous destruction of intrahepatic duct
PBC
Causes for pancreatic cancer
Smoking/chronic pancreatitis/DM
Alkaline tide
Increase blood pH after gastric acid secretion
5HT
vasoconstrict/diarrhea
Post GI/urethritis infection
Reactive arthritis—>seronegative spondyloarthritis
Group A/B strep
Group A—>S. Pyogenes
Group B—>S. Agalactiae
Acamprosate
Alcoholic after they stop drinking
Hyperthroydism might have elevated
Beta hCG
Variable expressivity
AD
Tensor tympani/stapedius muscle innervated by
V3
VII
Neuroendocrine tumors (small blue cell) APUD tumor
Pheo Neuroblastoma Medullary carcinoma of the thyroid Small cell lung cancer Carcinoid tumor
Neonate not developing well/umbilical hernia/big tongue
Think congenital hypothyroidism
After viral infection/granulomatous thyroid mass/tender
subacute granulomatous thyroiditis
Untreated hyperthyroid—>infection or trauma (stress)
Thyroid storm (tachy arrhythmia—>death)
Finely dispersed chromatin/thyroid mass
Papillary carcinoma
Pseudohypoparathyroidism/pseudopseudohypoparathyroidisim
Pseudo (defective Gs protein)—>hight PTH—>organ resistance to PTH—>low Ca—>knuckle knuckle dimple dimple
Pseudopseudo—>like pseudo but without organ resistance to PTH
Familial hypercalcemia hypocalcuric
Low Ca sensitivity (defective Ca sensing)—>excessive Ca renal reabsorption—>hypocalciuria
Pegvisomant
GH receptor antagonist
Anti glutamine acid decarboxylase antibodies
DM type 1
glucagonoma
Dermatitis (groin)/DM/depression/DVT
How to treat delirium?
Haloperidol
Tx for diptheria
Antitoxin (passive immunity)—>antibiotic—>active immunization
Aneuploidy
Abnormal number of chromosomes
Renal disease after an infection, kids
PSGN/minimal exchange
VU reflex/proteinaceous material in kidney/atrophic tubule
Chronic pyelonephritis
DIC/shock/placental abruption, what happen to the kidneys?
Diffuse cortical necrosis (infarction of both kidneys)
Renal failure consequences
High TG/inhibit conversion of T4 to T3—>functional hypothyroidism
Indapamide
Thiazide—>no high lipid
MC cause of diastolic heart failure
HTN
Leukemia that cause pancytopenia
Hairy cell/AML
Allergic triad
Rhinitis/dermatitis/asthma
Side effect of digoxin/promoted by
Cholinergic/yellow color vision/hyperK/arrhythmia
Renal deficiency and hypokalemia
MC malignant bone tumor
Multiple myeloma—>diaphysis
Bimodal age distribution/metaphysis of the bone
Osteosarcoma
Small blue cells/diaphysis of the bone/onion skin
Ewing sarcoma
Type of hypersensitivity for RA/lupus
Type III (IgM against Fc portion of IgG)
Gonococcal arthritis
Arthralgias/tenosynovitis/dermatitis (pustules)
Decrease in what is seen in lupus
C3/C4
Anti SRP/anti Mi 2 antibodies
Poly/dermatomyositis
Keratin cyst Neutrophil in corneum Target like Hep C Skin?
Seborrheic keratosis
Psoriasis
Erythema multiforme
Lichen planus
Leflunomide
Inhibit dihydrooroate dehydrogenase—>prevent pyrimidine synthesis—>suppress T cell proliferation
RA
Chlodiazepoxide
Benzo
Which vasculitis are granulomatous
Giant cell/Takayasu/Wegner/Churg Strauss
Father transmit to all daughters, MOI?
X linked dominate
sudden onset dyspnea
Think PE
Loud S2
Think about pul HTN or ASD
Lewy bodies
Contain alpha synuclein (eosinophilic)—>Parkinson
Tx for pseudomotor cerebri
Acetazolamide/weight lost
slow decrease in central vision/yellow deposit/tx?
Dry age related macular degeneration
Stop smoking/antioxidant
Child/calcification/cholesterol crystal/what brain tumor
Craniopharyngioma
Primitive small blue cell/brain tumor in kids?
Medulloblastoma
Corkscrew eosinophilic in kids brain tumor
Pilocystic astrocytoma
Vitamin B9
Folate