GI drugs

Question 1

What are the 2 pathways for ZE syndrome to cause increase acid production?

Answer 1

Stimulate gastrin and histamine receptor

Question 2

Are H2 blockers competitive or noncompetitive?

Answer 2

Competitive

Question 3

What drug is most effective against ZE syndrome?

Answer 3

PPI

Question 4

Why can’t you take sucralfate with other antacid drugs?

Answer 4

Because it needs an acidic environment to work

Question 5

What anti acid drugs have the fastest onset?

Answer 5

Antacid (Aluminum/Mg/Ca)

Question 6

What are the 2 receptors in chemoreceptor trigger zone? what other 2 receptors stimulate vomiting?

Answer 6

5HT3 and D2

M1 and NK-1

Question 7

Which receptor when stimulated, has antiemetic effect?

Answer 7

CB1 (weed)

Question 8

What are the 2 D antagonists drugs that are antiemetic? and what are their side effects?

Answer 8

Prochlorperazine/metochlopramide (also promotility)/movement disorders (pseudo parkinson)

Question 9

H1 or H2 blockers have antiemetic effect? example?

Answer 9

H1 (promethazine)