Misc 3 Flashcards
What antibodies is myasthenia gravis associated with?
ACh receptor Ab
What is the most common symptom of myasthenia gravis?
Ocular = ptosis
What antibodies are associated with dermatomyositis?
Anti-Mi-2
What antibodies are associated with Lambert Eaton myasthenic syndrome?
Voltage gated calcium channel ab
What is Whipple’s disease?
Bacterial infection caused by tropheryma whipplei
Causes malabsorption
Weight loss, abdo pain, diarrhea, arthritis
Common in farmers
Describe hereditary spherocytosis
Genetic condition causing sphere shaped RBCs
Causes hemolytic anemia
S+S: anemia, jaundice, splenomegaly, fatigue
Can cause pigmented gallstones
Howell Jolly bodies on blood smear
Describe acromegaly
Excess growth hormone - usually due to pituitary adenoma
Large hands + feet, forehead + jaw
Joint pain, thick skin, headaches, visual problems
What is the most common pathogen in cat bites?
Pasteurella multocida
What abx should be given post animal bite?
Co-amox or doxycycline + metronidazole
Describe DiGeorge syndrome
CATCH 22 Congenital heart abnormalities Abnormal facies Thymic aplasia cleft palate Hypocalcaemia + hypoparathyroidism
Ch22 deletion
Caused by dysmorphogenesis of 3rd + 4th pharyngeal pouches
RF for osteosarcoma
African 5-20 y/o (growing) or >65 (Paget's disease) Li-Fraumeni Males Metaphysis region stress
X ray findings for osteosarcoma
Moth eaten appearance
New bone formation = Codman’s triangle
Sunburst appearance
What does an onion skin, and soap bubble, appearance on x ray suggest?
Onion skin = Ewings sarcoma
Soap bubble = giant cell tumor (osteoclastoma)
What are the endocrine effects of a pituitary tumor?
Infertility Amenorrhea Galactorrhea Decreased libido Cushings disease Acromegly Hyperpigmentation Hypothyroidism Hypoadrenalism Hypogonadism Diabetes insipidus
What hormones are made in the pituitary?
GH LH FSH TSH ACTH Prolactin
What cranial nerves are affected by pituitary tumors?
3, 4, 5
Management of FB in eye
Topical abx
Topical cycloplegic for pain + photophobia
Eye shield
Describe Sheehans syndrome
Anterior hypopituitarism
Failure to lactate, amenorrhea, breast atrophy, hypothyroidism, adrenal cortical insufficiency
What surgeries can be performed to help in cerebral palsy?
Selective dorsal rhizotomy (cutting 1a sensory fibres)
Intrathecal baclofen pump insertion
What is an endocardial cushion defect?
congenital heart defect common in Downs
What is the leading cause of death in patients with multiple myeloma?
Bacterial infection (with encapsulated organisms eg strep pneumonia + Hib)
Describe haemachromatosis
Skin hyperpigmentation Polyuria, polydipsia Hepatomegaly Fatigue Impotence Athralgia Cardiomyopathy
Autosomal recessive disease causing accumulation of iron in organs
Describe primary biliary cholangitis (what is it, diagnostic test, LFT results, treatment, best prognostic indicator)
Inflammatory disease leading to fibrous obliteration of bile ducts
Diagnosed with AMA test
High ALP + GGT
Ursodiol is used to treat
Serum bilirubin is best prognostic factor
Describe DiGeorge syndrome
Failure of thymus, parathyroid + other facial structures to form properly
Reduced T cells + reduced immunity (poor thymus)
Primary hypoparathyroidism