Mini Exam 10 Flashcards
1
Q
Wendell Meredith Stanley
A
Discovered Tobacco Mosaic Virus (1935), first virologist
2
Q
TMV Structure
A
Long, skinny protein tube (capsid!) shielding RNA genome
3
Q
Virion
A
- infectious viral particle
- NOT A CELL (closer to parasite as it needs host to survive and multiply)
4
Q
Genome of Viruses
A
DNA or RNA (in virion)
5
Q
Capsid
A
- protein coat that surrounds a viral genome
- made of CAPSOMERES
6
Q
Envelope
A
- membrane surrounding a virus
- originates from HOST
- NEED glycoproteins
- optional
7
Q
Glycoproteins
A
-sugar-modified proteins embedded in membrane
- only in enveloped viruses
8
Q
Influenza
A
- segmented RNA virus
- air droplet/aerosol
- spread from birds or swine (ZOONOTIC)
- high mutation rate & reassortment = evolves FAST, new vaccine every year
9
Q
Virus Size Range
A
- 20- >200 nm oR 0.02 >0.2 micrometers
- can afford to be smaller bc it doesn’t have to do what living cells do; can pack light
10
Q
Host
A
Cell that virus infects
11
Q
Virus
A
- obligate INTRAcellular parasite
- SOME hijack host DNA replication and transcriptional machinery (DNA and Rretroviruses)
- ALL hijack host TRANSLATIONAL machinery (viruses don’t have ribosomes)
12
Q
Genome Replication
A
Make more genome
13
Q
Gene Expression
A
Make viral proteins
14
Q
Baltimore System
A
Classification according to how mRNA is made
15
Q
Genome types; segmented (reassortment)
A
- DNA or RNA
- circular or linear
- single or double stranded
- shore (6000 nts) or long (1,000,000 nts_
20
Q
Viral Growth Curve
A
of infective virions made over time;
