Midazolam

Question 1

Midazolam Class

Answer 1

Amnesic Agent, sedative/hypnotic, anticonvulsant, benzodiazepine, antianxiety

Question 2

Midazolam MOA

Answer 2

Binds to benzodiazepine receptors
Increases the inhibitory neurotransmitter GABA leading to decreased agitation, relaxation of skeletal muscles, and in high doses- sleep.

Question 3

Midazolam Indications (7)

Answer 3

Continuous or recurrent tonic-clonic seizures unrelated to eclampsia
Anxiety related to traumatic injury
Amnesic effects prior to synchronized cardioversion
Amnesic effects prior to transcutaneous pacing
Anxiety related to CPAP mask while SBP remains greater than 90 mmHG
Behavioral emergency related to excited delirium
Eclampsia unresponsive to magnesium sulfate

Question 4

Midazolam Contraindications (2)

Answer 4

Acute narrow-angle glaucoma

Hypotension/shock

Question 5

Midazolam Adult Seizure Dose

Answer 5

2.5mg IVP OR 5mg IM + 1 repeat

Question 6

Midazolam Pregnancy Classification

Answer 6

D (harmful to fetus)

Question 7

Midazolam Adult TCP/Synchronized Cardioversion Dose

Answer 7

2.5mg IVP OR 5mg IM + 1 repeat

Question 8

Midazolam Adult Excited Delirium Dose

Answer 8

2.5mg IVP or 5mg IM + 1 repeat (IM preferred)

Question 9

Midazolam Adult Anxiety Related to CPAP Dose

Answer 9

1mg IN or IM

Question 10

Midazolam Adult Eclampsia Dose

Answer 10

BHO 2.5mg IVP or 5mg IM

Question 11

Midazolam Adult Anxiety Related to Trauma Dose

Answer 11

BHO 2.5mg IVP or 5mg IM

Question 12

Midazolam Peds Seizure Dose

Answer 12

0.05mg/kg max 2.5mg IVP OR 0.1mg/kg max 5mg IM + 1 repeat

Question 13

Midazolam Peds Excited Delirium Dose

Answer 13

0.05mg/kg max 2.5mg IVP OR 0.1mg/kg max 5mg IM + 1 repeat

Question 14

Midazolam Peds TCP/Synchronized Cardioversion Dose

Answer 14

BHO 0.05mg/kg max 2.5mg IVP OR 0.1mg/kg max 5mg IVP

Question 15

Midazolam Peds Anxiety Related to Trauma Dose

Answer 15

BHO 0.05mg/kg max 2.5mg IVP OR 0.1mg/kg max 5mg IVP