Microtubules, Cilia and Flagela

Question 1

What are Microtubules

Answer 1

Large, hollow, cylindrical protein made up of Alpha and Beta Tubulin
Bipolar: Positive-end and Negative-end

Question 2

Microtubule requires ____________ for their production

Answer 2

ATP

Question 3

Antineoplastic drugs that inhibits Microtubules required for mitosis

Answer 3

Paclitaxel / Vancristine

Question 4

Which drug inhibits microtubules in inflammatory cells

Answer 4

Colchicine (Leukocytes)

Question 5

What are Motor proteins

Answer 5

Proteins that transport cellular contents by walking on MICROTUBULES

Question 6

What kind of motor proteins are there?

Answer 6

Dinein: Travels Anterograde ( + to -)
Kinesin: Travels Retrograde (- to +)

Question 7

What are Cilia and Flagella?

Answer 7

Organelles involved in cell mobility.

Question 8

What are Cilia and Flagella made of ?

Answer 8

Microtubules (Ring of 18 + 2 Central microtubules ) [9+2 formation]

Question 9

What is Kartagener syndrome?

Answer 9

Syndrome characterized by DYSFUNCTIONAL CILIA caused by a mutation in DINEIN

Question 10

Clinical features of Kartagener Syndrome?

Answer 10

Azoospermia, Dextrocardia, Situs Inversus, Respiratory tract infections.