Lipid Transport Flashcards
Lipids are soluble in _________ solvents
Non-Polar
Function of lipids
Source of energy
Signaling
Plasma membrane structure
How do Dietary Lipids get to Body cells
Via Lipoproteins
Where does chylomicron is produced?
Intestine (small intestine)
What is a chylomicron
Molecule composed of Lipid + Lipoprotein
Chylomicron express which surface protein
Apo B84
Where do Chylomicrons go after formation?
Lympathic channels
What happens once a Chylomicron runs out of fatty acids
It is processed by the Liver into cholesterol
Where do VLDL is produced?
Liver
Which surface protein is representative of VLDL?
Apo B100
What is the function of VLDL?
Same as Chylomicron
What happens once VLDL has run out of fatty acids
It becomes IDL
What routes do IDL have?
- Processed by liver
- Formation of LDL (High in cholesterol) and then absorbed by peripheral cells
LDL receptor interact with which molecule?
Apo B100
What are HDL function?
Donates ApoC2 and ApoE to chylomicron and VLDL
What is ApoC2 function?
- Activation of Lipoprotein Lipase = Breakdown of TG into FA
- Let FA enter into pheripheral cells
What is ApoE function?
Allows reuptake of remmant lipoproteins for recycling in the Liver
How does an inmature HDL becomes a Mature HDL?
Via LCAT enzyme (Activated by Lipoprotein A1)
Apo B48 function
Transport of Chylomicrons into lymphatics
Apo B100 function
Binds to LDL for uptake of LDL by peripheral cells (ENDOCITOSIS)
Abetalipoproteinemia inheritance pattern
Autosomal Recesive
Which surface protein is deficient in Abetalipoproteinemia?
ApoB48 / ApoB100
Abetalipoproteinemia is characterized by absence of which Lipoproteins?
Chylomicron
VLDL
LDL
Clinical features of Abetalipoproteinemia?
Severe fat malabsorption + FTT + Deficiency of fat-soluble vitamins
Treatment of Abetalipoproteinemia?
Vitamin E
Familial Hypercholesterolemia inheritance pattern
Autosomal Recessive
Which surface protein is deficient in Familial Hypercholesterolemia
LDL Receptor or Apo B100
Which Lipoproteins are increased in Familial Hypercholesterolemia
LDL (++)
Cholesterol
Familial Hypercholeterolemia is associated to
Early-onset Atherosclerosis (Accelerated)
Familial Hypercholeterolemia is associated to
Early-onset Atherosclerosis (Accelerated)
Familial Dyslipidemias follows which kind of inheritance pattern
Autosomal Recessive
Dysbetalipoproteinemia is caused by deficient
ApoE
Which lipoproteins are affected in Dysbetalipoproteinemia
Increased Chylomicrons and VLDL
Dysbetalipoproteinemia clinical features
Accelerated Atherosclerosis + Xanthomas
Familial Hypertriglyciridemia is caused by
Excessive production of VLDL
Familial Hypertriglyciridemia is associated to
Pancreatitis
Hyperchylomicronemia is caused by deficient
Lipoprotein Lipase or ApoC2
Hyperchylomicronemia is consistent with elevation of __________
Hyperchylomicronemia is consistent with elevation of __________
Chylomicrons / Triglycerides / Cholesterol
Hyperchylomicronemia clinical features
Pancreatitis + Xanthomas + Hepatosplenomegaly
Hyperchylomicronemia main feature for diagnosis
Creamy layer of fat in supernatant
Association between Hyperchylomicronemia and Atherosclerosis
NON-EXISTENT
Association between Hyperchylomicronemia and Atherosclerosis
NON-EXISTENT
