Ethanol metabolism

Question 1

Ethanol is converted in Acetaldehyde via which enzyme

Answer 1

Alcohol dehydrogenase

Question 2

Which final products does 1 molecule of ethanol produce ?

Answer 2

1 Acetate (Acetic acid)
2 NADH

Question 3

Acetaldehyde is converted to Acetic Acid via which enzyme

Answer 3

Acetaldehyde dehydrogenase

Question 4

Conversion of ethanol to acetaldehyde produces

Answer 4

1 NADH

Question 5

Conversion of acetaldehyde to Acetic Acid produces

Answer 5

1 NADH

Question 6

Ethanol metabolism requires a lot of _______ and creates a lot of ________

Answer 6

NAD+ / NADH

Question 7

Excess NADH produced in ethanol intoxication causes: (3 things)

Answer 7

1. Excess NADH causes conversion of Pyruvate into Lactic Acid = LACTIC ACIDOSIS
2. Excess NADH depletes oxaloacetate and inhibits Gluconeogenesis = FASTING HYPOGLYCEMIA
3. Excess NADH increases Dihydroxyacetone phosphate = Increased Glycerol = Increased fatty acids = HEPATIC STEATHOSIS

Question 8

Depletion of oxoloacetate is associated with ___________ in Ethanol intoxication

Answer 8

Fasting hypoglycemia by inhibition of Gluconeogenesis

Question 9

Where does ethanol metabolism occur

Answer 9

LIVER CELLS: Cytosol and Mitochondria

Question 10

Fomepizole inhibits which enzyme in ethanol metabolism

Answer 10

Alcohol Dehydrogenase

Question 11

Disulfiram ihibits which enzyme in ethanol metabolism

Answer 11

Acetaldehyde dehydrogenase