Microbiology (All Topics) Flashcards
Respiratory infections:
Outline the main features of Pneumonia and Bronchitis
Pneumonia:
- Mortality is 5 to 10%
- 20 to 40% are hospitalised
- 30 to 50% are Commuinity Acquired Pneumonia (CAP)
Respiratory infections:
Outline the symptoms and microscopitc findings of:
- S.Pneumonia
- H.Influenza
- M.Catarrhalis
- S.Auerus
- K.Pneumonia
Respiratory infections:
Outline the symptoms and features of:
- Legionella pneumophilia
- Mycoplasma pneumonia
- Chlamydia pneumonia
- Chlymydia psittaci
- Bordatella pertussis
- TB
- Coxiella Burnetti
Coxiella Burnetti:
- Domestic/farm animals
- Aerosol
- Diagnose with serology
- Treat with macrolides
Macrolide > Clarithromycin
Tetracycline > Doxycyline
Respiratory infections:
Outline the resipiratory tract infections associated with:
- HIV
- Neutropenia
- Bone Marrow transplant
- Splenectomy
- Cystic fibrosis
Respiratory infections:
Outline the daignosis of respiratory tract infections
Respiratory infections:
Outline the Antibiotics used for Community (Classical and Atypical) and Hospital Aquired Pneumonia
Respiratory infections:
What is the simplistic antibiotic framework for respiratory tract infections?
To simplify:
Just Gram positive:
- Amoxicillin
- Flucloxacillin
- Vancomycin
Mostly Gram positive, little gram negative:
- Coamoxiclav
- Cefuroxime
Clearly both:
- Cafotaxime
- Meropenem or Piperacillin & Tazobactam
Mostly Gram negative, little gram positive:
- Ciprofloxacin
Just Gram negative:
- Cefazidime
- Gentamicin
Atypical Pneumonia:
- Clarithromycin/doxycyline
PUO & Fever in the returning traveller
What is the definition of Pyrexia of Unknown Origin?
PUO & Fever in the returning traveller
- What is the approach to Neutropenic fever?
- What are the other key points to consider in PUO?
PUO & Fever in the returning traveller
What are the main causes of fever in the returning traveller?
PUO & Fever in the returning traveller
What are the Severity & Liver stage, Length of Rhythm, Blood film and treatment of P.Malaria
PUO & Fever in the returning traveller
What are the symptoms, investigations and management options for Typhoid?
Antibiotics:
- Cotrimidazole, Chloramphenicol or ampicillin
- (Multi-drug resistance) >> 3rd gen cephalosporin or azithromycin
PUO & Fever in the returning traveller
What are the Severity & Liver stage, Length of Rhythm, Blood film and treatment of P.Vivax
PUO & Fever in the returning traveller
What insect carries malara?
PUO & Fever in the returning traveller
What are the Severity & Liver stage, Length of Rhythm, Blood film and treatment of P.Ovale
P.Malaria
PUO & Fever in the returning traveller
What are the Severity & Liver stage, Length of Rhythm, Blood film and treatment of P.Falciparum
PUO & Fever in the returning traveller
What are the major features of sever or complicated Malaria?
IS PHARAOS:
- I: Impaired concoiusness/Seizures
- S: Shock
- P: Pulmonary oedema or ARDS
- H: Hypoglycaemia (<2.2mmol)/Haemoglobinueria
- A: Anaemia (Hb <8)
- R: Renal imapairement
- A: Acidosis (ph <7.3)
- O: Other indications
- S: Spontaneous bleeding/DIC
PUO & Fever in the returning traveller
What are the investigations for P.Falciparum?
PUO & Fever in the returning traveller
What is the treatment for P.Falciparum?
PUO & Fever in the returning traveller
What are the common signs of P.Falciparum?
PUO & Fever in the returning traveller
What are the symptoms of P.Falciparum?
Uncommon signs:
DDACC
- Diarrhoea
- Dark Urine
- Abdrominal pain
- Confusion
- Cough
PUO & Fever in the returning traveller
What is the definition of Classical PUO and give some examples
PUO Definition:
>38.3⁰C fever on several occasions persisting >3/52 without diagnosis despite >1/52 of intensive Ix
PUO & Fever in the returning traveller
What is the definition of Healthcare associated PUO and give some examples
PUO & Fever in the returning traveller
What is the definition of Neutropenic PUO and give some examples
PUO & Fever in the returning traveller
What is the definition of HIV Associated PUO and give some examples
Gastrointestinal Infections
What are the subtypes of the Microorganisms that causes Gastrointestinal Infections?
-
Anaerobic:
- Clostridia
- Botulinum
- Perefringes
- Difficile
- Clostridia
-
Aerobic:
- Bacillus Cerus
- Staph.Aureus
-
Lactose Fermenters:
- Gram negative Enterobacteriacae
- E.Coli
- ETEC
- EIEC
- EHEC
HUS
EPEC
-
Non-lactose Fermenters:
-
Salmonella
- Typhi
- Paratyphi
- H2S Producers
- Yersinia enterocoli
-
Salmonella
-
Miscellaneous:
- Vibrosis
- Cholera
- Parahaemolyticus
- Vulnificus
- Campylobacter jejuni
- Listeria monocytogenes
- Vibrosis
-
Protozoa:
- Entamoeba Histolytica
Gastrointestinal Infections
What are clinical symptoms and treatment of Clostridia Botulinum Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Clostridia Perfringes Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Clostridia Difficile Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Bacillus cereus Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Staph. Auerus Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of E.Coli Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Salmonella Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Enteritides Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Shigella Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Yersinia enterocoli Gastrointestinal Infections?
“CEMENTR”
- Cold enrichment: prefers 4 Degrees C
- Enterocolitis
- Mesenteric adenitis
- Erythema Nodosum
- Nectotising gramulomas
- Transmitted via animal comtaminated food
- Reactive arthritis
Gastrointestinal Infections
What are clinical symptoms and treatment of Cholera Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Parahaemolticus and Vulinficus Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Campylobacter jejuni Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Lysteria Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Entamoeba Histolytica Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms and treatment of Giardia lamblia Gastrointestinal Infections?
Gastrointestinal Infections
. What are clinical symptoms and treatment of Cryptosporidium Parvum Gastrointestinal Infections?
Gastrointestinal Infections
What are clinical symptoms of Mycobacteria Gastrointestinal Infections?
Gastrointestinal Infections
What are the clinical features of Viral Gastrointestinal Infections?
“RAPHEN”
- Rotavirus
- Adeovirus
- Polio
- Hep A
- Eenterovirus
- Norovius
Gastrointestinal Infections
What is the board classification of Gastroenteritis?
Hospital acquired infections:
What is the definition of a hospital acquired infection?
Hospital acquired infections:
What is the transmission route range of symptoms/risk factors pathology and management of Clostridium Difficile?
Hospital acquired infections:
What is the resistance profile of E.Coli?
What are the main risk factors and causative organisms of UTI?
Hospital acquired infections:
What are the causative organisms of Bacteraemia?
What are the causative organisms of Surgical site infections?
Neonatal and Childhood infections:
What are the key congenital infections, their investigations and management?
Neonatal and Childhood infections:
What are the risk factors, symptoms, investigations and management of early onset sepsis in neonatal infections?
Neonatal and Childhood infections:
What are the risk factors, symptoms, investigations and management of late onset neonatal infections?
Neonatal and Childhood infections:
What are the key organisms in Childhood infections, Paediatric Bacterial Meningitis, Respiratory tract infections and UTIs?
CNS Infection and Meningitis:
What is the subclassifications of meningitis and the causative organisms?
CNS Infection and Meningitis:
What is the aetiology, presentation, diagnosis and management of bacterial meningitis?
Viral Hepatitis:
What are the principles of CSF interpretation?
Viral Hepatitis:
What is the transmission, diagnosis and management of:
- Hep A
- Hep B
- Hep C
What is the transmission route of Hepatitis D and E?
Hepatitis D: RNA Virus that can only infect Hepatitis B patients
Hepatitis E: RNA Virus, transmitted by feacooral route. Common in india.
Viral Infections in Pregnancy:
What is the aetiology, presentation, diagnosis and management of Parovirus B19 in Pregnancy?
Viral Infections in Pregnancy:
What is the aetiology, presentation, diagnosis and management of Rubella in Pregnancy?
Viral Infections in Pregnancy:
What is the aetiology, presentation, diagnosis and management of Influenza and Measles in Pregnancy?
Vaccines:
What are the types of vaccine available?
Pandemic Flu:
What is/are:
- Antigenic drift
- Antigenic shift
- Pathogenesis
- Causes of severe outcomes of flu
- Antivirals for Influenza
Infective Endocarditis:
What is the history of Infective Endocarditis?
Infective Endocarditis:
What are the examination findings for Infective Endocarditis?
Infective Endocarditis:
What are the Investigations for Infective Endocarditis?
Infective Endocarditis:
What is the Dukes Criteria for Infective Endocarditis?
Infective Endocarditis:
What are the Infective Agents in Infective Endocarditis?
Infective Endocarditis:
What is the treatment for Infective Endocarditis?
Infective Endocarditis:
What are the indications for surgery in Infective Endocarditis?
Infective Endocarditis:
What precautions need to be taken in a patients suspected of Infective Endocarditis?
Wound, Bone and Joint Infections:
Describe the aetiology, organisms, presentations and management of Surgical site infections
Wound, Bone and Joint Infections:
Describe the aetiology, organisms, presentations and management of Septic Arthritis
Wound, Bone and Joint Infections:
Describe the aetiology, organisms, presentations and management of Osteomyelitis
Wound, Bone and Joint Infections:
Describe the aetiology, organisms, presentations and management of Prosthetic Joint Infection
Urinary Tract Infection:
What are the common organisms, presentations and management of Urinary Tract Infections?
Fungal Infections
Who are particularly vulnerable to fingal infections?
Why can they be difficult to diagnose?
What is the classification of fungal infections?
Antifungals
What are the targets and indications of:
- Polyene
- Azole
- Terbinafine
- Flucytosine
- Echinocandin
Fungal Infections
What are the key superficial fungal infections and how are they diagnosed?
Herpes Infections
What are the symptoms of the following:
- Asymptomatic CMV
- Congenital CMV
Congential: LIMITED JHCC:
- Late progressive sensorineural deafness
- IUGR
- Microcephaly
- Impaired IQ
- Thrombocytopenia
- Encephalitis
- Death
- Jaundice
- Hepatosplenomegaly
- Chorioretinitis
- Cytomegalic inclusion disease (13%)
Herpes Infections
What is/are the aetiology, investigations and treatment of Cytomegalovirus?
Investigtions: STICHH
-
Serology
- Immunocompromised: limited diagnostic value
- Immunocompitent: CMV IgM & IgG (IgG low avidity in first infection)
- Tissue
- Immunoflourescence
- Cell culture
- Histopathology
-
Heterphile Antibodies
- Paul Bunnel monospot: clumping of sheep RBCs
Herpes Infections
What are the symptoms investigations and management of Roseola infections?
Herpes Infections
What are the features of oral HSV1/HSV 2 infections?
Herpes Infections
What are the symptoms of Encephalitis from HSV1/HSV2 infections?
Herpes Infections
What are the symptoms of skin infections from HSV1/HSV2 infections?
Herpes Infections
What are the symptoms of Varicella Zoster infections?
Herpes Infections
What are the symptoms, investigations and management of Shingles infections?
Herpes Infections
What are the features of:
- Infectious mononucleosis
- Burkitt’s lymphoma
Alongside Nasopharyngeal Ca and Post-transplant lymphoproliferative disease, these are the possible causes of EBV.
Herpes Infections
What are the features of HHV8 infections?
Herpes Infections
What are the features of Neonatal HSV1/HSV2 infections?
Herpes Infections
What are the symptoms of the following:
- CMV Mononucelosis
- Immunocompromised CMV
Immunocompromised CMV: “GRAPH/GRAF B”
- GI: colitis
- Retinitis (Retinitis=AIDS)/Radiculopathy
- Addisons disease
- Pneumonitis (in BMT patients)
- Hepatitis
- Fever
- Bone Marrow supression
Herpes Infections
What are the features of ocular HSV1/HSV 2 infections?
Herpes Infections
What are the features of genital HSV1/HSV 2 infections?
Herpes Infections
What are the investigations of skin infections from HSV1/HSV2 infections?
ELISA= HSV-2 IgG enzyme-linked immunosorbent assay
Herpes Infections:
What is the management of skin infections from HSV1/HSV2 infections?
Herpes Infections
What are the investigations for Varicella Zoster infections?
Herpes Infections
What is the management of Varicella Zoster infections?
Pregnancy:
- Can give Aciclovir within 24hrs of exposure
- IVIG VZV can be give up to 10 days post exposure
Herpes Infections
What are features of Varicella Zoster infections in pregnancy?
Herpes Infections
What is Mollarets Meningitis?
Herpes Infections
What are the CT/MRI findings in Encephalitis from HSV1/HSV2 infections?
Herpes Infections
What are the CSF findings in Encephalitis from HSV1/HSV2 infections?
Herpes Infections
What is the management of Encephalitis from HSV1/HSV2 infections?
Herpes Infections:
What are the features of:
- Nasopharyngeal Ca
- Post transplant lymphoproliferative disease
Alongside Infectious mononucleosis and Burkitt’s lymphoma, possible causes of EBV
Fungal Infections
What are the symptoms, investigations and management of Candida infections?
Fungal Infections
What are the symptoms, investigations and management of Crypotococcus infections?
Fungal Infections
What are the symptoms, investigations and management of Aspergillus infections?
Herpes Infections
What are the classifications of Herpes infections?
Herpes Infection Classifications:
-
Epitheliotropic
- CMV
- Infected cells swell (hence megavirus)
- Roseola virus
- CMV
-
Neurotropic
- HSV1 & HSV2: dsDNA. No animal reservoir. Persistent latent phase in DRG. Lytic infection of fibroblasts + epithelial cells. Transmitted via muco-cutaneous contact
-
VZV:dsDNA. Droplet spread. Viral replication in LNs, then in liver + spleen then vesicular rash (rash ~48hrs after infection). 14/7
- Shingles
- Chickenpox
-
Lymphocytic
- EBV
- HHV8
Fungal Infections
What are the key deep fungal infections and how are they diagnosed?
Diagnosed: clinical details, lab results and imaging
Main types:
- Candida
- Aspergillus
- Cryptococcus
Gastrointestinal Infections
What is/are the incubation period, duration and comments of E.Coli infections?
Gastrointestinal Infections
What is/are the incubation period, duration and comments of Shigella infections?