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Lecom pathology year 2 > Microbiology 9-Toxins > Flashcards

Microbiology 9-Toxins Flashcards

1
Q

what is the effect and mechanism of toxin A and B of C. difficile

A

cytoplasmic (cells lose filaments); deamination of Rho GTPase

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2
Q

what is the effect and mechanism of heat-stable enterotoxin of E.coli

A

diarrhea; activates host guanylate cyclase

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3
Q

what is the effect and mechanism of enterotoxin of C. difficile

A

hemorrhagic diarrhea; acts as membrane

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4
Q

what is exotoxin A of Pseudomonas aeruginosa similar to

A

diphtheria toxin

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5
Q

what is the effect and mechanism of heat-stable enterotoxin of Yersinia enterocolitica

A

diarrhea; activates host guanylate cyclase

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6
Q

what is the effect and mechanism of edema factor A of bacillus anthracis

A

edema; adenylate cyclase

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7
Q

what is the mechanism of action of type 3 cytotoxins

A

effect actin cytoskeleton

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8
Q

what is the effect and mechanism of shiga toxin

A

kills cells; inactivates 60S ribosomes

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9
Q

what is the effect and mechanism of adenylate cyclase toxin AB of bordetella pertussis

A

inhibits/kills white cells; adenylate cyclase

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10
Q

what is the Heat-labile enterotoxin AB5 of E. coli identical to

A

cholera toxin

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11
Q

what is the cytotoxin of E.coli identical to

A

like shiga toxin

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12
Q

what is the effect and mechanism of beta-toxin

A

cytolytic; sphingomyelinase

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13
Q

what is all exotoxin activity found in

A

Lipid A

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14
Q

what is the effect and mechanism of corynebacterium diphtheria

A

kills cells; ADP-ribosylates EF-2

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15
Q

what is the effect and mechanism of alpha toxin of clostridia spp

A

necrosis in gas gangrene, cytolytic, lethal; phospholipase C

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16
Q

what is the effect and mechanism of pertussis toxin AB5 of bordetella pertussis

A

many hormonal effects; ADP ribosylation of G protein

17
Q

what is the effect and mechanism of delta-lysin

A

cytolytic; detergent-like action

18
Q

what is the effect and mechanism of alpha-toxin of S. aureus

A

hemolytic, leukocytic, paralysis of smooth muscle; pore-forming toxin

19
Q

what is the effect and mechanism of type 4 cytotoxins of Legionella pneumophila

A

inhibit endosome maturation; interfere with Rab protein function

20
Q

what is the effect and mechanism of lethal factor A of bacillus anthracis

A

pulmonary edema; protease

Lecom pathology year 2 (18 decks)

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