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Lecom pathology year 2 > chapter 25- skin > Flashcards

chapter 25- skin Flashcards

1
Q

what layer of the skin is the stem cell layer

A

basal layer

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2
Q

what layer of the skin has the desmosomes

A

spinosum

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3
Q

what layer of the skin has agranulate cells (anucleate cells)

A

corneum

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4
Q

what type of hypersensitivity is contact dermatitis with exposure to poison ivy and nickel jewelry

A

type 4 HSR

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5
Q

what is the term for well-circumscribed, salmon-colored plaques with silvery scale

A

psoriasis

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6
Q

where does psoriasis usually occur

A

extensor surfaces and scalp

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7
Q

what is the common environmental trigger of psoriasis

A

trauma

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8
Q

what is the term for pruritic, planar, polygonal, purple papules

A

lichen planes

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9
Q

where is commonly involved in lichen plants

A

wrists, elbows and oral mucosa

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10
Q

what chronic infection is associated with lichen plants

A

chronic hepatitis c

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11
Q

what is the term for autoimmune destruction of desmosomes

A

pemphigus vulgaris

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12
Q

what antibodies are formed in pemphigus vulgaris

A

IgG Antibodies against desmoglein

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13
Q

what is the term for autoimmune destruction of hemidesmosomes

A

bulls pemphigoid

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14
Q

what type of immunofluorescence is seen with bulls pemphigoid

A

linear

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15
Q

what is the term for autoimmune destruction of IgA at tips of dermal papillae

A

dermatitis herpetiformis

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16
Q

what disease is strongly associated with dermatitis herpetiformis

A

celiac disease

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17
Q

what infection is erythema multiform most commonly associated with

A

HSV

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18
Q

what should you think of with lesler-trelat sign

A

seborrheic keratosis

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19
Q

what carcinoma does leser-trelat sign suggest

A

underlying carcinoma of GI tract

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20
Q

what areas of the body are often involved in acanthuses nigricans

A

groin or axilla

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21
Q

what is acanthuses nigricans most often associated with

A

insulin resistance or malignancy

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22
Q

what is the classic location of basal cell carcinoma

A

upper lip

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23
Q

what is the usual location of squamous cell carcinoma

A

usually on face, classically involving lower lip

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24
Q

what is the precursor to squamous cell carcinoma

A

actinic keratosis

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25
what are melanocytes derived from
neural crest
26
what is vitiligo due to
autoimmune destruction of melanocytes
27
what enzyme is defective in albinism
tyrosinase
28
what is melasma associated with
pregnancy and oral contraceptives
29
where does acroy lentiginous melanoma occur
mostly on palms or soles in dark skin individuals (not related to UV light exposure)
30
what is the cause of molluscum contagious
pox virus
31
Traumatic lesion breaking the epidermis and causing a raw linear area; often self-induced
Excoriation
32
Thickened, rough skin;usually the result of repeated rubbing
Lichenification
33
Circumscribed, flat lesion distinguished from surrounding skin by color
Macule, patch
34
Separation of nail plate from nail bed
Onycholysis
35
Elevated, dome shaped or flat topped lesion.
Papule or nodule
36
Discrete, pus-filled raised lesion
Pustule
37
Dry, horny, platelike excrescence; usually result of imperfect cornification
Scale
38
Diffuse epidermal hyperplasia
Acanthodians
39
Abnormal, premature keratinization within cells below stratum granulosum
Dyskeratosis
40
Hyperplasia of stratum granulosu, often due to intense rubbing
Hypergranulosis
41
Linear pattern of melanocyte proliferation within epidermal basal cell layer
Lentiginous
42
Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae
Papillomatosis
43
Intercellular edema of epidermis
Spongiosis
44
Loss of intercellular cohesion between keratinocytes
Acantholysis
45
Diffuse epidermal hyperplasia
Acanthodians
46
What is the most often acquired activating mutation with melanocytic Nevus
Ras signaling pathway
47
What do individual with dysplastic nevus syndrome have inherited loss of function mutations of
CDKN2A
48
What nevus has the diagnostic architectural feature of non-nested dermal infiltration, often with associated fibrosis
Blue nevus
49
What activating mutation is common with seborrheic keratoses
FGFR3
50
What can be described as round, flat, coinlike, waxy plaques that vary in diameter
Seborrheic keratoses
51
Where do accrine poroma adenexal tumors occur
Predominantly on palms and soles where sweat glands are high
52
Where does cylindrical adnexal tumors primarily occur
Forehead and scalp
53
Where do syringomas typically occur
Lower eyelids
54
What are sebaceous adenomas associated with internal malignancy
Muir-torre syndrome
55
What does sebaceous carcinoma arise from
Meibomian glands of eyelids
56
What is it called when actinic keratosis involved the lips
Actinic checklist is
57
What skin layer is mostly involved with actinic keratosis
Stratum corneum
58
What activating mutation is associated with basal cell carcinoma
Hedgehog pathway signaling
59
What cells are primarily involved in mycosis fungoides
CD4+ T cells
60
What is defective with icthyosis
Defective desquamation
61
What type of hypersensitivity is urticaria
Type 1
62
What cells are most responsible for erythema multiforme
Skin-homing CD8+ cytotoxic T cells
63
What is the term for bleeding points when scale is lifted from plaque in psoriasis
Auspitz sign
64
What sohuld you think of with colloid/civatte bodies
Lichen planus
65
What antibodies are present with bulbous pemphigoid
Antibodies against BPAG2 (part of hemidesmosome)
66
What are the typical sites of involvement for bullous pemphigoid
Inner aspect of thighs, flexor surfaces of forearms, axillae, groin and lower abdomen
67
What is the term form inflammatory reaction in subcutaneous adipose tissue taht may preferentially affect the lobules of fat or the CT that separates fat into lobules
Panniculitis

Lecom pathology year 2 (18 decks)

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