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First Aid Online Review > Microbio Pages 187-191 > Flashcards

Microbio Pages 187-191 Flashcards

1
Q

Which topoisomerases do FQ inhibit

A

II & IV

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2
Q

What drugs shouldn’t be paired with FQ?

A

antacids

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3
Q

MOR of FQ

A

efflux pumps, plasmid mediated resistance

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4
Q

Do FQ’s have any cardiac side effects

A

torsades de pointes (inc QT interval)

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5
Q

Why are FQs CI in preganancy

A

damage to cartilage in fetus

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6
Q

FQ’s are used against

A

mostly gram neg UTI and GI infections, Pseudomonas, Neisseria, B. anthracis

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7
Q

Clinical use of Daptomycin

A

MRSA skin infections, VRE, endocarditis

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8
Q

Which path is daptomycin CI in?

A

pneumonia (inactivated by surfactant)

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9
Q

AA of daptomycin?

A

myopathy, rhadomyolysis

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10
Q

Which bugs is metronidazole DOC for?

A

Giardia, Entamoeba, Trichomona, C. Diff, Gardnerella vag

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11
Q

does metronidazole affect taste

A

yes. metallic taste

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12
Q

Prophylaxis for M. Tuberculosis?

A

INH

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13
Q

Prophylaxis for MAI?

A

Azithromycin

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14
Q

doe the therapy change for M. leprae depending on stage?

A

Yes tuberculous= dapsone +rifampin

Lepromatous= dapsone + rifampin + clofazimine

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15
Q

Which rifamycin is DOC in HIV patients?

A

Rifabutin

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16
Q

AA of Rifampin

A

red/orange urine, CytP450 inducer

17
Q

INH AA?

A

hepatotoxicity, neurotoxicity, CytP450 inhibitor

18
Q

INH neurotoxicity Tx?

A

B6 prophylaxis

19
Q

MOR for INH

A

decreased KatG expression

20
Q

AA for Pyrzinamide

A

Hyperuricemia, hepatotoxicity

21
Q

AA for Ethambutol

A

optic neuropathy (red green color blind)

22
Q

Prophylaxis for UTIs

23
Q

Prophylaxis for gonorrhea exposure

A

Ceftriaxone

24
Q

Prophylaxis for syphilis

A

Penicillin G

25
Q

Prophylaxis for dental procedure

A

Amoxicillin

26
Q

Prophylaxis for HIV pts (CD count

A

SMP-TMX (PCP)

27
Q

Prophylaxis for HIV pts (CD count

A

Azithromycin (MAI)

28
Q

TX for acinobacter baumannii

A

colisitin/polymyxin B&E

29
Q

Tx for fungal meningitis?

A

intrathecal Amphotericin B

30
Q

fingual infecting the nail tx?

A

terbinafine (onychomiciosis)

31
Q

TX for Candida thrush

A

Nystatin (swish & swallow)

32
Q

Combo therapy for cryptococcal meningitis

A

Amphotericin B + Flucytosine

33
Q

AA of Azoles?

A

CyrP450 inhibition, gynaecomastia, liver dysfunction

34
Q

Tx for Toxoplasmosis?

A

Pyrmethamine

35
Q

Tx for Trypanosoma bruceii

A

Suramin/Melarsoprol

36
Q

Tx for for Trypanosoma cruzi?

A

Nifurtimox

37
Q

Tx for Leishmaniasis?

A

Na Stibogluconate

First Aid Online Review (13 decks)

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