Microbio Pages 187-191 Flashcards
Which topoisomerases do FQ inhibit
II & IV
What drugs shouldn’t be paired with FQ?
antacids
MOR of FQ
efflux pumps, plasmid mediated resistance
Do FQ’s have any cardiac side effects
torsades de pointes (inc QT interval)
Why are FQs CI in preganancy
damage to cartilage in fetus
FQ’s are used against
mostly gram neg UTI and GI infections, Pseudomonas, Neisseria, B. anthracis
Clinical use of Daptomycin
MRSA skin infections, VRE, endocarditis
Which path is daptomycin CI in?
pneumonia (inactivated by surfactant)
AA of daptomycin?
myopathy, rhadomyolysis
Which bugs is metronidazole DOC for?
Giardia, Entamoeba, Trichomona, C. Diff, Gardnerella vag
does metronidazole affect taste
yes. metallic taste
Prophylaxis for M. Tuberculosis?
INH
Prophylaxis for MAI?
Azithromycin
doe the therapy change for M. leprae depending on stage?
Yes tuberculous= dapsone +rifampin
Lepromatous= dapsone + rifampin + clofazimine
Which rifamycin is DOC in HIV patients?
Rifabutin