Biochem Pages 112-115

Question 1

For Lipid synthesis, which transporter molecule is required for initiation?

Answer 1

Citrate shuttle

Question 2

For Lipid catabolism/B-oxidation, which transporter molecule is required for initiation?

Answer 2

Carnitine shuttle

Question 3

Name the 3 ketone bodies produced?

Answer 3

Acetone, B-OH butyrate, acetoacetate

Question 4

Which ketone body can’t be detected in urinalysis?

Answer 4

B-OH butyrate

Question 5

Define acute starvation, and processes it consists?

Answer 5

Days 1-3 of starvation= acute
glycogenolysis first (reserves deplete after day 1), release of FFA, hepatic gluconeogenesis

Question 6

Define chronic starvation, and processes it consists?

Answer 6

Day 3 and beyond = chronic
brain starts using FFA into ketone bodies for fuel. Protein starts breaking down which will eventually lead to organ failure

Question 7

What is the rate limiting step in cholesterol synthesis, and connection to pharm?

Answer 7

HMG CoA reductase converts HMG CoA to mevalonate, statins are comp inhibitors (hypercholesteremia)

Question 8

Apo CII mutation is found in?

Answer 8

Type I dyslipidemia, AR (hyperchylomicronemia)

Question 9

What happens in Type IIa hypercholesteremia?

Answer 9

AD deficiency of LDL receptors

Question 10

What accumulates in Type IV dyslipidemia?

Answer 10

AD increased production of VLDL, TG

Question 11

Which dyslipidemia shows corneal acrus and xanthelesma?

Answer 11

Type IIa also has presentation of Achilles xanthomas