Microbio Pages 167-171

Question 1

Lab values for viral hepatitis

Answer 1

ALT > AST

Question 2

Lab values for alcoholic hepatitis

Answer 2

AST > ALT

Question 3

Lab values in Hep B infection (acute/prodromal)

Answer 3

HBsAg, HBeAg, IgM

Question 4

Lab values in Hep B infection (Window)

Answer 4

Anti-HBe, IgM

Question 5

Lab values in Hep B infection (Chronic)

Answer 5

HBsAg, IgG,
Anti HBe (low infectivity)
HBeAg (high infectivity)

Question 6

Lab values in Hep B infection (Recovery)

Answer 6

Anti HBs, Anti HBe, IgG

Question 7

Lab values in immunized for Hep B infection

Answer 7

Anti HBs only

Question 8

Structural genes in HIV

Answer 8

env, gag, pol

Question 9

What does the envelope gene code for

Answer 9

gp120 (attachment to CD4+ TH cells),

gp41 (fusion and entry into cells)

Question 10

What does the gag gene code for

Answer 10

p24 (capsid protein)

Question 11

What does the pol gene code for

Answer 11

RT, Asp Protease, Integrase

Question 12

Attachment to which co receptor leads to early HIV infection?

Answer 12

CCR5

Question 13

Attachment to which co receptor leads to late HIV infection?

Answer 13

CXCR4

Question 14

which phase of HIV infection does the virus replicate in LN?

Answer 14

latent phase, pt can feel fine for years

Question 15

Which HIV test has high sensitivity to rule out pts?

Answer 15

ELISA

Question 16

complication with ELISA?

Answer 16

FP -babies born to infected mother

FN- 1-2 months of early acute phase of infection

Question 17

When is AIDS confirmed?

Answer 17

CD4+ count

Question 18

Opportunistic infections (CD4 count

Answer 18

Candida, EBV, B. henselae, HHV-8, Crytosporidium, HPV

Question 19

Opportunistic infections (CD4 count

Answer 19

T. gondii, JC virus, P, jirovecii

Question 20

Opportunistic infections (CD4 count

Answer 20

Aspergillus, Cryptococcus, Candida, CMV, EBV, Histoplasma, MAI

Question 21

Difference in EBV infection in CD count 500 and 100

Answer 21

500- Oral hairy leukoplakia

100- B cell NHL

Question 22

Difference in Candida infection in CD count 500 and 100

Answer 22

500- Oral thrush

100- Esophagitis (white plaques on endoscopy)

Question 23

Difference b/w leukoplakia and thrush

Answer 23

thrush- scrapable (candida)

leukoplakia- unscrapable (EBV)

Question 24

Ring enhancing lesions on CT scan (multiple)

Answer 24

Toxaplasmosis

Question 25

Ring enhancing lesions on CT scan (solitary)

Answer 25

EBV caused CNS lymphoma

Question 26

What infection does JC virus cause? with or without ring lesions?

Answer 26

Progressive multifocal leukoencephlopathy (PMLE), non ring enhancing