micro week 1 review

Question 1

viral tropism HSV 1

Answer 1

encephalitis of the temporal and frontal lobes

Question 2

viral tropism of poliovirus

Answer 2

anterior horn cells

Question 3

JC virus viral tropism

Answer 3

oligodendrocytes - progressive multifocal leukoencephalopathy

Question 4

rabies viral tropism

Answer 4

hippocampus and cerebellum

Question 5

dorsal root ganglia viral tropism

Answer 5

varicella zoster virus

Question 6

leptomeninges viral tropism

Answer 6

lymphocytic choriomeningitis

Question 7

These are all enveloped, RNA viruses transmitted by mosquitoes

Answer 7

Togaviruses - Eastern Equine Encephalitis virus, et al. Flaviviruses - West Nile, Zika Bunyaviruses - La Crosse virus

Question 8

what do activated T cells do in the blood brain barrier

Answer 8

they usually come and go or come and die

Question 9

B cells only enter the CNS during _____ . If antigen is in CNS, local ________ secretion ensues

Answer 9

inflammation antibody

Question 10

astrocytes express ________ and produce ________

Answer 10

TLR4 TGF beta

Question 11

CNS tissue MF, highly phagocytic, poor APCs. Can be activated to produce inflammatory mediators

Answer 11

microglia

Question 12

Mast cells perivascular in meninges produce TNF, facilitates entry of ________ during inflammation

Answer 12

T cells