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Cc2mtap > MI PROFILE CREATINE KINASE (CK) > Flashcards

MI PROFILE CREATINE KINASE (CK) Flashcards

1
Q

A transferase that focuses on the transfer of phosphate group between substrates

a. AST
B.ALT
C. GGPT
D. CK

A

D. CK

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2
Q

Involved in the storage of high-energy creatine phosphate in muscle cells

a. AST
B.ALT
C. GGPT
D. CK

A

D. CK

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3
Q

In CK, the highest activities are in the
____________

a. skeletal muscle
b. heart
c. brain
d. liver
e. a,b,c
f. a,b,d

A

e. a,b,c

a. skeletal muscle
b. heart
c. brain

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4
Q

Phosphate is transferred from _____ to Creatine to produce Creatine Phosphate

a. carbon dioxide
b.glycogen
c. atp
d. lipase

A

c. atp

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5
Q

Creatine originates in the_____

A

liver from amino acids

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6
Q

3 AMINO ACIDS associate in creatinine

A

Glycine
Arginine
Methionine.

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7
Q

T OR FALSE
CK IS Not specific to the heart muscles

A

TRUE

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8
Q

STRUCTURE OF CREATINASE KINASE

A. MONOMERIC molecule
b. dimeric molecule

A

b. dimeric molecule

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9
Q

TRUE OR FALSE

CREATINE KINASE composed of 2 monomer sub-units such as the M (muscle) and the B (brain)Type)

A

TRUE

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10
Q

REACTION PRODUCT OF CK

A. CREATINE PHOSPHATE+ ADP
B. CREATINE PHOSPHATE+NADPH

A

A. CREATINE PHOSPHATE+ ADP

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11
Q

FORWARD REACTION IN CK

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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12
Q

↓ in absorbance at 340 nm is determined IN CK

A.Tanzer-Gilvarg
B.Oliver-Rosalki

A

A.Tanzer-Gilvarg

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13
Q

Optimum pH is 9.0

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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14
Q

PK – Pyruvate Kinase IS THE PRIMARY ENZYME

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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15
Q

TANZER- GILVARG

REACTION PRODUCT

A. LACTATE+NADH
B. LACTATE + NAD

A

B. LACTATE + NAD

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16
Q

Increased in absorbance at 340 nm is determined IN CK

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

A. Oliver-Rosalki A
REVERSE REACTION

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17
Q

(left to right)

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B. tanzer

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18
Q

(right to left)
WITH OPTIMUM PH OF 6.8
A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

A. Oliver-Rosalki

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19
Q

REACTION OF OLIVER ROSALKI

A. 6- PHOSPHOGLUCONATE+ NADPH + H
B. A. 6- PHOSPHOGLUCONATE+ NAD+ H

A

A. 6- PHOSPHOGLUCONATE+ NADPH + H

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20
Q

In normal healthy serum, the predominant CK activity comes from the ______-

A. HEART
B. MUSCLE
C. LIVER
D. SKELETAL

A

B. MUSCLE

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21
Q

For bedridden patients, CK ACTIVITY IS

A. DECREASE
B. INCREASE

A

A. DECREASE

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22
Q

Hemolysis cause false ↑ OR ↓ CK activIty?

A

↑ increase

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23
Q

CK is inactivated by _______

a. ATP
B. LIGHT
C. LYSED RBC

A

B. LIGHT

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24
Q

REFERENCE VALUE FOR CK IN MALES

A. 25-130 U/L
B. 15-160 U/L
C. . 15-150 U/L

A

B. 15-160 U/L

25
REFERENCE VALUE FOR CK IN FEMALES A. 15-130 U/L B. 15-160 U/L C. . 15-150 U/L
A. 15-130 U/L
26
CK-MB REFERENCE VALUE A. <6% of total CK B. <8% of total CK
A. <6% of total CK
27
Slowest mobility toward the anode; least anodic/ farthestfrom the anode A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
C. CK-3/ CK-MM/ Muscle type
28
2nd fastest to migrate toward the anode A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
B. CK-2/CK-MB/Hybrid type
29
Migrate fastest toward the anode A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
A. CK-1/CK-BB/ Brain Type
30
Significant quantities are found in heart tissues A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
B. CK-2/CK-MB/Hybrid type
31
Major isoenzyme in striated muscle and in normal serum A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
C. CK-3/ CK-MM/ Muscle type
32
Increase- acute myocardial infraction A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
B. CK-2/CK-MB/Hybrid type
33
Nearest to the anode A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
A. CK-1/CK-BB/ Brain Type
34
Highest concentration in CNS, GItract, and uterus(pregnancy) A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
A. CK-1/CK-BB/ Brain Type
35
In health human serum, it is less than 1% sometimes won’t appear in electrophoresis test A. CK-1/CK-BB/ Brain Type B. CK-2/CK-MB/Hybrid type C. CK-3/ CK-MM/ Muscle type
A. CK-1/CK-BB/ Brain Type
36
After MI, CK-MB (>6%) levels begin to rise within ___hours a. 4-8 hrs b. 5-6 hrs c. 12-24 hours, d. 48-72 hours
a. 4-8 hrs
37
After MI, CK-MB (>6%) peak hours a. 4-8 hrs b. 12-72 hrs c. 12-24 hours, d. 48-72 hours
c. 12-24 hours,
38
After MI, CK-MB (>6%) levels begin returns to normal levels within _________hours a. 48-72 b.47-72
a. 48-72 hrs
39
reference value for CK-MM A. 94-98% B. 2-6%
94-98%
40
reference value for CK-MB: A. 94-98% B. 2-6% C. 3-5%
B. 2-6%
41
CK-BB A. 94-98% B. 2-6% C. 3-5% D.<1%
D.<1%
42
**First enzyme** to elevate among patients with acute MI A. CK-BB B. CK-MB C. CK-MM
B. CK-MB
43
First **protein** to elevate among patients with acute MI A. MYOGLOBIN B. AMYLASE C. CK-MM D. CK-MB
A. MYOGLOBIN
44
Peak hours of ck-mb A.12-24hrs B. 5-8hrs C. 48-72 hours D5-9 hrs
A.12-24hrs
45
CK MB RETURN TO NORMAL LEVELS ON WHAT TIME? A. 48-72 hours B. 6-10 hrs C.5-8 hrs D. 2 days
A. 48-72 hours
46
The highest elevation of CK-MM is seen in
Duchene Muscular Dystrophy
47
Would improve the diagnostic capacity of the laboratory/hospital because of its specificity of the isoenzyme to an organ/tissue
Ck isoenzyme measurement
48
IN LABORATORY- 2 POSIBLE TEST ARE DONE to diagnose MI
Total Ck Ck isoenzyme
49
less diagnostic because it is not tissue specific; found in different kinds of tissue A. Ck isoenzyme B. Total ck
B. Total ck
50
more diagnostic/more specific target; diagnosis is possible A. Ck isoenzyme B. Total ck
A. Ck isoenzyme
51
**A CK-BB or CK-MM that is coupled with other molecules.** A. Mitochondrial CK (CK-Mi) B. Micro-CK C. MACRO-ck
C. MACRO-ck
52
A CK Isoenzyme bound to the mitochondrial membrane A. CK (CK-Mi) B. Micro-CK C. MACRO-ck
A. CK (CK-Mi) mitochondrial
53
complexed with Antibodies (IgG or IgA) A. CK-BB B. CK-MM
A. CK-BB
54
complexed with LPP (lipoprotein) A. CK-BB B. CK-MM
B. CK-MM
55
complexed with Antibodies (IgG or IgA) A. CK-BB B. CK-MM
CK-BB
56
Migrates midway between CK-MM and CK-MB
Macro-CK
57
Increase level of this is possible cell necrosis/ cell severe damage. A. CK (CK-Mi) B. Macro-CK
A. CK (CK-Mi)
58
Migrates/ found cathodal to CK- MM.
CK (CK-Mi)

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