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Cc2mtap > MI PROFILE CREATINE KINASE (CK) > Flashcards

MI PROFILE CREATINE KINASE (CK) Flashcards

1
Q

A transferase that focuses on the transfer of phosphate group between substrates

a. AST
B.ALT
C. GGPT
D. CK

A

D. CK

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2
Q

Involved in the storage of high-energy creatine phosphate in muscle cells

a. AST
B.ALT
C. GGPT
D. CK

A

D. CK

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3
Q

In CK, the highest activities are in the
____________

a. skeletal muscle
b. heart
c. brain
d. liver
e. a,b,c
f. a,b,d

A

e. a,b,c

a. skeletal muscle
b. heart
c. brain

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4
Q

Phosphate is transferred from _____ to Creatine to produce Creatine Phosphate

a. carbon dioxide
b.glycogen
c. atp
d. lipase

A

c. atp

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5
Q

Creatine originates in the_____

A

liver from amino acids

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6
Q

3 AMINO ACIDS associate in creatinine

A

Glycine
Arginine
Methionine.

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7
Q

T OR FALSE
CK IS Not specific to the heart muscles

A

TRUE

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8
Q

STRUCTURE OF CREATINASE KINASE

A. MONOMERIC molecule
b. dimeric molecule

A

b. dimeric molecule

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9
Q

TRUE OR FALSE

CREATINE KINASE composed of 2 monomer sub-units such as the M (muscle) and the B (brain)Type)

A

TRUE

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10
Q

REACTION PRODUCT OF CK

A. CREATINE PHOSPHATE+ ADP
B. CREATINE PHOSPHATE+NADPH

A

A. CREATINE PHOSPHATE+ ADP

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11
Q

FORWARD REACTION IN CK

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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12
Q

↓ in absorbance at 340 nm is determined IN CK

A.Tanzer-Gilvarg
B.Oliver-Rosalki

A

A.Tanzer-Gilvarg

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13
Q

Optimum pH is 9.0

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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14
Q

PK – Pyruvate Kinase IS THE PRIMARY ENZYME

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B.Tanzer-Gilvarg

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15
Q

TANZER- GILVARG

REACTION PRODUCT

A. LACTATE+NADH
B. LACTATE + NAD

A

B. LACTATE + NAD

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16
Q

Increased in absorbance at 340 nm is determined IN CK

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

A. Oliver-Rosalki A
REVERSE REACTION

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17
Q

(left to right)

A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

B. tanzer

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18
Q

(right to left)
WITH OPTIMUM PH OF 6.8
A. Oliver-Rosalki
B.Tanzer-Gilvarg

A

A. Oliver-Rosalki

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19
Q

REACTION OF OLIVER ROSALKI

A. 6- PHOSPHOGLUCONATE+ NADPH + H
B. A. 6- PHOSPHOGLUCONATE+ NAD+ H

A

A. 6- PHOSPHOGLUCONATE+ NADPH + H

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20
Q

In normal healthy serum, the predominant CK activity comes from the ______-

A. HEART
B. MUSCLE
C. LIVER
D. SKELETAL

A

B. MUSCLE

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21
Q

For bedridden patients, CK ACTIVITY IS

A. DECREASE
B. INCREASE

A

A. DECREASE

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22
Q

Hemolysis cause false ↑ OR ↓ CK activIty?

A

↑ increase

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23
Q

CK is inactivated by _______

a. ATP
B. LIGHT
C. LYSED RBC

A

B. LIGHT

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24
Q

REFERENCE VALUE FOR CK IN MALES

A. 25-130 U/L
B. 15-160 U/L
C. . 15-150 U/L

A

B. 15-160 U/L

25
Q

REFERENCE VALUE FOR CK IN FEMALES

A. 15-130 U/L
B. 15-160 U/L
C. . 15-150 U/L

A

A. 15-130 U/L

26
Q

CK-MB REFERENCE VALUE

A. <6% of total CK
B. <8% of total CK

A

A. <6% of total CK

27
Q

Slowest mobility toward the anode; least anodic/ farthestfrom the anode

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

C. CK-3/ CK-MM/ Muscle type

28
Q

2nd fastest to migrate toward the anode

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

B. CK-2/CK-MB/Hybrid type

29
Q

Migrate fastest toward the anode

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

A. CK-1/CK-BB/ Brain Type

30
Q

Significant quantities are found in heart tissues

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

B. CK-2/CK-MB/Hybrid type

31
Q

Major isoenzyme in striated muscle and in normal serum

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

C. CK-3/ CK-MM/ Muscle type

32
Q

Increase- acute myocardial infraction

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

B. CK-2/CK-MB/Hybrid type

33
Q

Nearest to the anode

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

A. CK-1/CK-BB/ Brain Type

34
Q

Highest concentration in CNS, GItract, and uterus(pregnancy)

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

A. CK-1/CK-BB/ Brain Type

35
Q

In health human serum,
it is less than 1% sometimes won’t
appear in electrophoresis test

A. CK-1/CK-BB/ Brain Type
B. CK-2/CK-MB/Hybrid type
C. CK-3/ CK-MM/ Muscle type

A

A. CK-1/CK-BB/ Brain Type

36
Q

After MI, CK-MB (>6%) levels begin to rise within ___hours

a. 4-8 hrs
b. 5-6 hrs
c. 12-24 hours,
d. 48-72 hours

A

a. 4-8 hrs

37
Q

After MI, CK-MB (>6%) peak hours
a. 4-8 hrs
b. 12-72 hrs
c. 12-24 hours,
d. 48-72 hours

A

c. 12-24 hours,

38
Q

After MI, CK-MB (>6%) levels begin returns to normal levels within _________hours
a. 48-72
b.47-72

A

a. 48-72 hrs

39
Q

reference value for CK-MM

A. 94-98%
B. 2-6%

40
Q

reference value for CK-MB:
A. 94-98%
B. 2-6%
C. 3-5%

41
Q

CK-BB
A. 94-98%
B. 2-6%
C. 3-5%
D.<1%

42
Q

First enzyme to elevate among patients with acute MI

A. CK-BB
B. CK-MB
C. CK-MM

43
Q

First protein to elevate among patients with acute MI

A. MYOGLOBIN
B. AMYLASE
C. CK-MM
D. CK-MB

A

A. MYOGLOBIN

44
Q

Peak hours of ck-mb

A.12-24hrs
B. 5-8hrs
C. 48-72 hours
D5-9 hrs

A

A.12-24hrs

45
Q

CK MB RETURN TO NORMAL LEVELS ON WHAT TIME?

A. 48-72 hours
B. 6-10 hrs
C.5-8 hrs
D. 2 days

A

A. 48-72 hours

46
Q

The highest elevation of CK-MM is seen in

A

Duchene Muscular Dystrophy

47
Q

Would improve the diagnostic capacity of the laboratory/hospital because of its specificity of the isoenzyme to an organ/tissue

A

Ck isoenzyme measurement

48
Q

IN LABORATORY- 2 POSIBLE TEST ARE DONE to diagnose MI

A

Total Ck
Ck isoenzyme

49
Q

less diagnostic because it is not tissue specific; found in different kinds of tissue

A. Ck isoenzyme
B. Total ck

A

B. Total ck

50
Q

more diagnostic/more specific target; diagnosis is possible

A. Ck isoenzyme
B. Total ck

A

A. Ck isoenzyme

51
Q

A CK-BB or CK-MM that is coupled with other molecules.

A. Mitochondrial CK (CK-Mi)
B. Micro-CK
C. MACRO-ck

A

C. MACRO-ck

52
Q

A CK Isoenzyme bound to the mitochondrial membrane

A. CK (CK-Mi)
B. Micro-CK
C. MACRO-ck

A

A. CK (CK-Mi) mitochondrial

53
Q

complexed with Antibodies (IgG or IgA)

A. CK-BB
B. CK-MM

54
Q

complexed with LPP (lipoprotein)

A. CK-BB
B. CK-MM

55
Q

complexed with Antibodies (IgG or IgA)

A. CK-BB
B. CK-MM

56
Q

Migrates midway between CK-MM and CK-MB

57
Q

Increase level of this is possible cell necrosis/ cell severe damage.

A. CK (CK-Mi)
B. Macro-CK

A

A. CK (CK-Mi)

58
Q

Migrates/ found cathodal to CK- MM.

A

CK (CK-Mi)

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