LDH ISOENZYMES Flashcards
LDH-1(HHHH)
TISSUE
A. Heart, RBC
B.Liver
C.Lung, spleen, pancreas
d. Skeletal Muscle
A. Heart, RBC
Disorders (↑) in LDH-1(HHHH)
a. Renal Infarction, Megaloblastic anemia
b. Myocardial Infarction, Hemolytic anemia
c. Hepatic injury
d. Skeletal muscle injury
b. Myocardial Infarction, Hemolytic anemia
LDH-2 (HHHM)
TISSUE
A. Heart, RBC
B.Liver
C.Lung, spleen, pancreas
d. Skeletal Muscle
A. Heart, RBC
LDH-3(HHMM)
TISSUE
A. Heart, RBC
B.Liver
C.Lung, spleen, pancreas
d. Skeletal Muscle
C.Lung, spleen, pancreas
LDH-4(HMMM)
A. Heart, RBC
B.Liver
C.Lung, spleen, pancreas
d. Skeletal Muscle
B.Liver
LDH-5(MMMM)
A. Heart, RBC
B.Liver
C.Lung, spleen, pancreas
d. Skeletal Muscle
d. Skeletal Muscle
Disorders (↑) in LDH- 2(HHHM)
a. Renal Infarction, Megaloblastic anemia
b. Myocardial Infarction, Hemolytic anemia
c. Hepatic injury
d. Skeletal muscle injury
a. Renal Infarction, Megaloblastic anemia
Disorders (↑) in LDH- 3(HHMM)
a. Renal Infarction, Megaloblastic anemia
b. Myocardial Infarction, Hemolytic anemia
c. PULMONARY EMBOLISM
d. Skeletal muscle injury
c. PULMONARY EMBOLISM
Disorders (↑) in LDH- 4(HMMM)
a. Renal Infarction, Megaloblastic anemia
b. Myocardial Infarction, Hemolytic anemia
c. PULMONARY EMBOLISM
d. HEPATIC INJURY
d. HEPATIC INJURY
Disorders (↑) in LDH- 5(MMMM)
a. Skeletal muscle Injury
b. Myocardial Infarction, Hemolytic anemia
c. PULMONARY EMBOLISM
d. HEPATIC INJURY
a. Skeletal muscle Injury
Normal Values range of LDH- 5(MMMM)
A. 20-30%
B.20-25%
C. 30-40%
D. 7-15%
E. 5-15%
E. 5-15%
Normal Values range of LDH-1(HHHH)
A. 20-30%
B.20-25%
C. 30-40%
D. 7-15%
E. 5-15%
A. 20-30%
Normal Values range of LDH-2(HHHM)
A. 20-30%
B.20-25%
C. 30-40%
D. 7-15%
E. 5-15%
C. 30-40%
Normal Values range of LDH-3(HHMM)
A. 20-30%
B.20-25%
C. 30-40%
D. 7-15%
E. 5-15%
B.20-25%
Normal Values range of LDH-4(HMMM)
A. 20-30%
B.20-25%
C. 30-40%
D. 7-15%
E. 5-15%
D. 7-15%
Not normally seen among healthy induvial; only demonstrated when the
patient has the ff conditions:
Drug hepatotoxicity, Obstructive jaundice and arteriosclerotic failure
LDH6 (Alcohol Dehydrogenase)
fastest to migrate//closest to anode;
H-Heart; M-muscle; LDH 1
slowest/farthest
LDH 5
Concentration in Healthy Human Serum:
A. LDH 2 > 1 > 3 > 4 > 5
B. LDH 1 > 2 > 3 > 4 > 5
A. LDH 2 > 1 > 3 > 4 > 5
Acute MI and Intravascular Hemolysis
A. LDH 2 > 1 > 3 > 4 > 5
B. LDH 1 > 2 > 3 > 4 > 5
B. LDH 1 > 2 > 3 > 4 > 5
↑ LDH-1 & ↑ CK-MB
a. Intravascular Hemolytic Condition
b. AMI
b. AMI
↑ LDH-1 & Normal CK-MB
INTRAVASCULAR HEMOLYTIC