Aspartate Aminotransferase (AST) Flashcards
Ast is also known as?
A. Serumgluta- oxaloacetictransaminase
B. Serum glutamic-oxaloacetictransaminase
C. Serum glutamic-pyruvic transaminase
B. Serum glutamic-oxaloacetictransaminase
AST
Catalyzes the transfer of an amino group between ____ and _____
A. Alanine and 2 monomer
B.alanine and pyruvic acids
C. Alanine and aspartate
D. aspartate and α-keto acids
D. aspartate and α-keto acids
AST
Involved in synthesis and degradation ———- ) of AA in the liver
A. anabolism & catabolism
B. y-glutamyl peptides
C. phosphomonoester bonds
D. p-nitrophenol
A. anabolism & catabolism
AST
For aminotransferases, the coenzyme required is _______
A. VITAMIN B12
B. VITAMIN B6
C. pyridoxal phosphate
d. hydrogen transfer enzyme
B AND C
TRUE OR FALSE AST
Enzymes does similar catalytic activity but differ in physical,
biochemical and immunologic properties
TRUE
most abundant and predominant AST isoenzyme in the healthy human serum
A. Cytoplasmic AST
B. Mitochondrial AST
A. Cytoplasmic AST
INCREASE In serum indicates possible cell necrosis/ severe damage to the
cell
A. Creatine Kinase (CK)
B. Mitochondrial AST
C. Lactate Dehydrogenase
B. Mitochondrial AST
After Acute Myocardial Infarction, AST levels begin to rise in____hours, peak at 24 hours and return to normal in 5 days
A. 5 TO 6 HRS
B. 6-8 HOURS
C.8 HOURS
D. 6-9 HOURS
B. 6-8 HOURS
Also ↑ in hepatocellular and skeletal muscle disease
A. AST
B.GGT
C.ALT
D.CK
A. AST
Released to greater degree in cases of chronic disorders of the liver with
progressive damage
A. AST/SGOT
B.AST/GGT
C.ALT
D.CK
A. AST/ SGOT
type of cofactor that serves as second substrate for enzymatic reaction
COENZYMES
Tightly bound enzyme to coenzyme
Prosthetic group
example of COENZYMES
NAD
NADP
NAD MEANS?
Nicotinamide adenine dinucleotide
IF the NAD is used as coenzymes, it will convert into 2 forms when acted
by oxidoreductase enzyme by what kind of reaction?
REDOX REACTION
