Alanine Aminotransferase (ALT) Flashcards
Alanine Aminotransferase (ALT) also known as?
A. Serum glutamic-pyruvic transaminase (SGPT)
B. Alkaline Orthophosphoric
C. Ast
D. SGOT
A. Serum glutamic-pyruvic transaminase (SGPT)
Alanine Aminotransferase (ALT)
Catalyzes the transfer of an amino group between —- and —-
A. Alanine and α-keto acids
B. aspartate and α-keto acids
C. Alanine and α-ketoglutarate
C. Alanine and α-ketoglutarate
Increased in hepatocellular disorders (considered as liver specific enzyme)
A. Ast
B. Ck-MB
C. ALT
D. SGOT
ALT
Enumerate the 4 uses of ALT
- acute inflammatory conditions of the liver
- hepatitis treatment and effects of drug therapy specially among patients with chronic diseases
- screening test for post transfusion hepatitis and occupational toxic exposure
- screen blood donors if donor is suspected of having hepatitis B.
”AI HDC PT OTE SB
Shows the result of AST/ALT ratio result
De Ritis Ratio
Differentiates the cause of hepatic disorder
De retis ratio
Ratio >1
A. viral in origin; ALT is greater
B. non-viral origin; AST is greater
B. non-viral origin; AST is greater
viral in origin; ALT is greater
A. Ratio <1
B. Ratio >1
A. Ratio <1
The coupling enzyme in Alanine Aminotransferase (ALT)
A. alcohol dehydrogenase
B. Lactate Dehydrogenase
C. malate dehydrogenase (MD)
B. Lactate Dehydrogenase
The enzymatic absorbance in ALT IS. — in absorbance at 340nm.
A. Decrease
B.increase
Decrease
ALT reference range
A. 6-37 U/L
B. 5-30 U/L
C.6-40 U/L
A. 6-37 U/L
Reaction product in ALT
A.LACTATE + NAD+
B.LACTATE + NADH+
A.LACTATE + NAD+
Major organ affected in AST/ SGOT
A. Heart
B.lungs
C.kidney
Heart
Major organ affected in ALT/SGPT
A. Heart
B. Skeletal
C. Muscle
D.liver
Liver
Substrate in ALT
A. Alanine Ketoglutaric Acid
B Aspartic Alpha Ketoglutaric Acid
a. Alanine Ketoglutaric Acid
