Alp Isoenzymes Flashcards
Two fractions of LIVER ALP
MAJOR LIVER. And .FAST LIVER
predominant in serum; responsible for
liver ALP abundance; healthy individuals
A.fast liver
B. Major liver
Major liver
(α1) band – closest to the anode; responsible for fast migration of the liver ALP
A.major
B. Fast liver
B. Fast liver
Second fastest to migrate
A.liver alp
B. Bone alp
C. Placenta alp
D.intestinal alp
B. Bone alp
Bone disorder: Osteitis deformans also known as ——disease
A.panget disease
B.pagets disease
C. Osteoblast disorder
pagets disease
Most heat stable fraction
A.liver alp
B. Bone alp
C. Placenta alp
D.intestinal alp
C. Placenta alp
3rd fastest to migrate
A.bone alp
B. Placental alp
Placental alp
Placental alp will ↑ in pregnancy on how many weeks?
A.2-6 weeks of gastation
B. 16th to 20th weeks of gastation
B. 16th to 20th weeks
Pathologic condition of placental alp is called
A. Carninoplacental alkaphose
B. Carcinoplacental acidosis
Carcinoplacental alkaphose
Slowest moving fraction in Alp
Intestinal alp
blood groups B or O secretors
A. Bone alp
B.placental alp
C. Intestinal alp
Intestinal alp
when they consume fatty meals, ——- ALP are elevated
A. Bone
B.placental
C. Liver alp
D. Intestinal
Intestinal
↑ in fatty meal consumption and GIT disorders
Intestinal alp
In chemical inhbitors
A.bone
B.liver
C.intestinal
Intestinal
Placental and Intestinal ALP are inhibited
A. Levamisole reagent
B. 3M urea
C. Phenylalanine
C. Phenylalanine
used to inhibit Bone and Liver ALP
A. Levamisole reagent
B. 3M urea
C. Phenylalanine
Levamisole reagent
inhibit the Bone ALP
A. Levamisole reagent
B. 3M urea
C. Phenylalanine
3M UREA
Total ALP elevation by Liver or Bone ALP is differentiated by heating of serum at ——
A.8c for 10mins
B.50c for 10 mins
C.56c for 10mins
C.56c for 10mins
When heated at 56c for 10 mins
Liver ALP residual activity is
A. ↓ to >20% (greater than)
B. ↓ to <20% (less than)
A. ↓ to >20% (greater than)
When heated at 56c for 10 mins
BONE alp residual activity is
A. ↓ to >20% (greater than)
B. ↓ to <20% (less than)
B. ↓ to <20% (less than)
most stable to labile Arrangement
A. Placenta>Intestine>Liver>Bone
B. Placenta>Liver>Bone>Intestinal
A. Placenta>Intestine>Liver>Bone
the focus because is the major isoenzyme in the serum
A. Bone alp
B. Liver alp
C. Intestinal alp
A and B
used in diagnosing cancer; could also be used as tumor marker
A. Nagao ALP
B. Regan ALP
C. Carcinoplacental ALP
C. Carcinoplacental ALP
Breast, Lung, and Gynecological cancers
A. Nagao ALP
B. Regan ALP
C. Carcinoplacental ALP
B. Regan ALP
Bone ALP co-migrator
A. Nagao ALP
B. Regan ALP
C. Carcinoplacental ALP
B. Regan ALP
Adenocarcinoma of the pancreas and Bile duct, Pleural Cancer
A. Nagao ALP
B. Regan ALP
C. Carcinoplacental ALP
A. Nagao ALP
used to inhibit Regan and Nagao
A. L-leucine
B. Phenylalanine
B. Pheny
used to inhibit Nagao only
L- leucine
