Mets

Question 1

most mets to the brain are what?

Answer 1

carcinomas

Question 2

where are most mets located?

Answer 2

in the cerebrum at the white/gray junction

Question 3

an epidural met to the spinal cord is most likely what?

Answer 3

an extension of mets to vertebrae or paravertebral

Question 4

what are the common primary locations for brain mets

Answer 4

lungs (50%), breast 15%, skin 10%

Question 5

what are the common primary locations for intramedullary spinal cord mets?

Answer 5

lungs

Question 6

what are the commonest primary tumors for an epidural spinal cord compression

Answer 6

breast 20%, lungs 15%, prostate 10%, lymphoma 10%

Question 7

mets to the leptomeninges?

Answer 7

lymphoma and leukemia, melanoma, breast, lung, GI

Question 8

clinical signs/symptoms

Answer 8

headache, papilledema, focal weakness, hemiparesis, ataxia, sensory disturbances (cerebral)
cord compression, sensory disturbances, back pain, weakness (spinal cord)

Question 9

imaging for mets

Answer 9

discrete, multiple with contrast enhancement and surrounding edema

Question 10

what types of mets are hemorrhagic?

Answer 10

lung, renal, chorio, melanoma

Question 11

histologic features of mets?

Answer 11

VERY sharply demarcated from brain parenchyma, tumor necrosis

Question 12

prognosis

Answer 12

very poor