Meningioma

Question 1

cell type

Answer 1

meningothelial

Question 2

when are these tumors multiple (hint: genetic cause)

Answer 2

NF2

Question 3

what age group is there that usually presents with meningioma

Answer 3

50-70

Question 4

what sex is more affected by these?

Answer 4

women

Question 5

what is the epidemiology in NF2 patients

Answer 5

younger people with equivalence among sexes

Question 6

location of most meningiomas?

Answer 6

cerebral convexities

Question 7

clinical features of meningiomas?

Answer 7

headache, seizure

Question 8

imaging features of meningiomas?

Answer 8

attached to the dura, pick up contrast, well circumscribed

Question 9

gross features of meningiomas?

Answer 9

firm, rubbery, sometimes lobulated masses

Question 10

what are the three subtypes of meningioma histologically?

Answer 10

meningothelial, fibroblastic, transitional

Question 11

what are the features of meningothelial meningioma?

Answer 11

epithelioid cells, R/O, rectangular to polygonal cells, with lots of cytoplasm

Question 12

what are the features of fibroblastic meningioma?

Answer 12

elongated cells that appear elliptical or spindle shaped and have collagenous ECM

Question 13

what histologic feature are shared by both

Answer 13

psammoma bodies

Question 14

what are the genetic features of meningioma?

Answer 14

22q12 loss

NF2 (tumor suppressor) which is on chr22 but may not be the only relevant gene that is lost