Medulloblastoma Flashcards
1
Q
definition
A
cells invade and met through the CSF
2
Q
age/sex
A
less than 16; 1.85:1
3
Q
location
A
vermis of the cerebellum
posterior fossa generally
4
Q
signs/symptoms
A
h/v lethargy, truncal ataxia, gait disturbance
5
Q
imaging
A
solid, contrast enhancing
6
Q
mets
A
through the CSF usually to subarachnoid space
7
Q
histology
A
small blue cells, rosettes, tumor necrosis
+/- GFAP or synaptophysin/neurofilaments
8
Q
genetics
A
isochromosome 17q (17p loss) - but probably not p53 relevant MYC upreg
9
Q
prognosis
A
good
