Diffusely Infiltrating Astrocytoma Flashcards
1
Q
what is the natural history of this tumor?
A
usually progresses to become invasive
2
Q
what grade of tumor is this?
A
2
3
Q
what age group is most commonly affected? sex?
A
20-45; 1.2:1 M:f
4
Q
what location do these usually take?
A
cerebrum (cerebellum very rare)
5
Q
what are the clinical signs and symptoms of a diffusely infiltrating astrocytoma?
A
seizures, changes in sensation or weakness
6
Q
how do DIA appear on imaging?
A
ill defined, irregular shaped, and do not enhance with contrast
7
Q
on histology how do the astrocytes distinguish themselves from epithelial, melanocytic and hematolymphoid cells?
A
GFAP (glial fibrillary acidic protein)
8
Q
what are the genetic mutations common to DIA?
A
isocitrate dehydrogenase (R132H substitution) that produces high levels of 2-hydroxyglutarate p53 is commonly mutated in those that progress to glioblastoma (WHO grade 4)
9
Q
how does having a genetic mutation affect prognosis?
A
improves it
