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Toxicology > Metals > Flashcards

Metals Flashcards

0
Q

Metallothion proteins?

A

1st line of defense against metal poisoning, when saturated -> toxic effect

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1
Q

Specificity EDTA? WHat is it?

A

chelating agent, low.

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2
Q

Accumulation of Arsenic?

A

hair, nails, skin, bones

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3
Q

effect of Arsenic?

A

binds -SH groups –> inactivation of enzymes.

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4
Q

Chelating agent arsenic?

A

dimercaprol

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5
Q

Effect of Arsine? (AsH3)

A

hemolysis

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6
Q

Arsenite + Selenite given together –> ?

A

cancelled toxicity.

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7
Q

CHelating agent for Pb?

A

EDTA

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8
Q

where does Pb accumulate?

A

bones (years) organs (weeks/months)

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9
Q

What is affected by Pb?

A

Blood

Brain

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10
Q

What does Pb do?

A

mimics other metals (cofactors in enzymes?) –> enzyme activity lowered

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11
Q

Pb in CNS?

A

interfered w/ release of Glutamate –> learning & memory impaired.

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12
Q

Pb in PNS?

A

demyelination –> signaltransduction impaired.

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13
Q

Chelating agent for Cadmium?

A

BAL (Dimercaprol)

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14
Q

Cadmium persistent?

A

yes

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15
Q

Cadmium accumulation?

A

kidney

16
Q

effect of Cadmium?

A

lowers [Ca2+] (because level of Ca mod. by liver)
–> Ca2+ taken from bones as compensation
=> osteoporose-like symptoms

17
Q

example of cadmium outbreak?

A

itai itai disease. (rice grown in Cd water)

18
Q

toxic Hg compund?

A

MethylHg

19
Q

How does Hg get into food chain?

A

some bacteria prod. MethylHg –> accumulation in food chain

20
Q

How does Hg cross BBB?

A

Transporters used.

21
Q

Examples of Hg outbreaks?

A
  • Minamata disease

- Basra poison grain disaster (fungicide w/ methylHg used)

22
Q

Thalliumsulfate used as?

A

rodenticide

23
Q

effect of thallium?

A

Tl+ has similar diameter as K+ => distr. via Na/K pump

mainly on CNS

24
Q

Chelating agent Thallium?

A

DDTC

Toxicology (9 decks)

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