Endocrine Disruptors Flashcards
0
Q
Antiestrogenic compounds?
A
- Phytohormones
- Xenohormones (not natural)
- synth. hormones
1
Q
Modes of action?
A
- change in hormone kinetics (Synth., secret. & transp., metabol & excret.)
- change on hormone receptor level (agonist, antagonist, inducer, repressor, downstream signals)
2
Q
ligans of estrogen receptor?
A
- genistein (soybeans) => antagonist
- diethylstilbestrol
- DDT (agonist)
3
Q
Use diethylstilbestrol?
effect? Who affected?
A
prevent abortion in unstable pregnancies
effect on children of patient.
infertility, sperm cound low, microphallus, abortions, vaginal adenocarcinoma, malform. of inner&outer sex organs.
