Inhalation Toxicology Flashcards
0
Q
low H2O soluble compounds show…
A
no immediate effect, when experienced usually too late –> damage to alveoli
1
Q
high H2O soluble compounds show…
A
immediate, strong toxic effect
2
Q
Classification by physiologic effects?
A
A: Irritation, damage of airway mucuous membranes
B: Interference w/ chem. compounds
C: Toxins displacing O2
3
Q
High H2O soluble compounds affect…?
A
Eyes, pharynx, trachea
4
Q
intermediate H2O soluble compounds affect…?
A
bronchius
5
Q
low H2O soluble compunds affect…?
A
Alveoli, capillaries
6
Q
Pulmonary oedema?
A
liquid into alveoli etc.
7
Q
Irritants of the lung? (A)
A
- Formaldehyde
- Ammonia
- Bromine,Chlorine,Fluorine
- Sulphur dioxide (Wintersmog)
- Nitric oxides (NOx)
- Phosgene (disruptor of blood-air-barrier)
8
Q
Inhalation toxins? (B)
A
- CN
- CO (inhibition of O2 transport, displaces O2 from Fe in Hb)
- CO2/N2 (Displace O2 st high conc.)
- H2S
9
Q
Aerosoles? (C)
A
e.g. Asbestos
necrosis of alveolar cells
can lead to tumors.
