Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Respiratory > mesothelioma + Asbestos > Flashcards

mesothelioma + Asbestos Flashcards

1
Q

mesothelial cells come from which germ layer?

A

Mesoderm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mesothelial membrane lines which structure in the lung?

A

pleural space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what do mesothelial cells do in response to a noxious stimuli?

A

proliferate.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

is the amount of asbestos exposure related to the severity of mesothelioma?

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

can you get mesothelioma with only low exposure to asbestos?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

why does asbestos increase cancer risk?

A

DNA damaged + altered gene expression from inflammation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the most common asbestos related lung disease?

A

Pleural plaques

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Asbestosis is what exactly?

A

fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

asbestosis is obstructive or restrictive lung disease?

A

restrictive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

is the amount of asbestos exposure related to the severity/chance of getting asbestosis?

A

yes

more asbestos = worse asbestosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

asbestos coupled with smoking gives a synergistic increase in risk to what disease?

A

Lung cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

someone smokes and has asbestos exposure,

which disease now has a big increase in risk?

A

Lung cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mesothelioma is a cancer of what specific structure in the lung?

A

pleura

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

of mesothelioma pts how many has a history of asbestos exposure?

A

85%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Latent period for mesothelioma?

A

20-40 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which types of asbestos is worst for causing mesothelioma?

what is the colour of this asbestos?

A

Crocidolite

blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mesothelioma often causes what pleural disease,

can be seen on CXR?

A

pleural effusion

18
Q

main risk factors for mesothelioma?

-3

A

Old
male
asbestos exposure

19
Q

can mesothelioma metastasise?

if so to what structure most commonly?

A

yes

contralateral lung

20
Q

how will mesothelioma pt describe their chest pain most commonly?

A

dull, achy diffuse chest pai

21
Q

can you get pleuritic chest pain with mesothelioma?

A

yes

22
Q

can you get haemoptysis with mesothelioma?

A

no

23
Q

pt has mesothelioma.

stony dull percussion is noted. what is this specifically a sign of?

A

pleural effusion

24
Q

symptoms of mesothelioma?

- 8

A 
Progressive SOB 
Cough 
Chest pain – dull, achy 
Pleuritic chest pain 
Fatigue
fever
night sweats
weight loss
25
Q

pt arrives with cough, SOB, chest pain and history of asbestos exposure.

what is 1st line Ix?

A

CXR

26
Q

features of mesothelioma on a CXR?

- 3 things

A

pleural effusion
pleura thickened
lower zone fibrosis

27
Q

pt has CXR with findings suspicious of mesothelioma.

What is the next imaging Ix?

what counts as positive finding for mesothelioma on this IX?
- 3 things

A

Contrast enhanced CT

pleural thickened, pleural effusion, big lymph nodes

28
Q

CXR shows pleural effusion.

what Ix would you do now specifically in regards to the pleural effusion.

A

aspirate and send to lab.

29
Q

what is the Gold.S Ix for diagnosing mesothelioma?

A

Thoracoscopy with biopsy

30
Q

you want to do thoracoscopy to check for mesothelioma, but this is CI.

alternative Ix to thoracoscopy in this context?

A

image guided fine needle biopsy

31
Q

most mesothelioma pts will have what treatment?

A

chemotherapy

32
Q

what surgery is potentially available for mesothelioma?

- 2

A

pneumonectomy

pleurectomy

33
Q

why is surgery normally contraindicated in mesothelioma pts?

A

because of metastases

34
Q

in regards to mesothelioma which chemicals are used in chemotherapy?
- 2

A

Cisplatin

Pemetrexed

35
Q

median survival for mesothelioma?

A

1 year

36
Q

define pneumonectomy

A

remove part of lung

37
Q

according to oxford handbook you usually need a biopsy to diagnose.

true or false?

A

true

38
Q

other mesothelial layers in the abdomen are never effected by asbestos exposure.

true or false?

A

false

are effected, but very rarely

39
Q

is radiotherapy a risk factor for mesothelioma?

A

yes

40
Q

is chemotherapy a risk factor for mesothelioma?

A

no

41
Q

which virus is a risk factor for mesothelioma?

A

simian virus 40

42
Q

when is thoracoscopy indicated as an IX for suspected mesothelioma?

A

when aspiration and lab analysis of pleural effusion is inconclusive/CI.

Respiratory (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions