Mesenchymal Neoplasms Flashcards
What are the characteristics of mesenchymal cells?
variable exfoliation
indistinct, wispy cytoplasmic borders
spindle shaped, fusiform, stellate cells
cell individually arranged
more oval shaped nuclei than epithelial cells
Tissue of origin?
Benign or malignant?
Tumor type?
mesenchymal
malignant
Leiomyosarcoma
Which mesenchymal tumors may need histopathology to determine biological behavior?
Muscle tumors= Leiomyoma/sarcoma & myxoma/sarcoma
Cartilagenous tumors= chondroma/sarcoma
Via which route do mesenchymal tumors typically metastasize?
hematogenous routes
Describe the characteristics of malignancy in this sample? What general classification would this tumor be?
Anisokaryosis, mitotic figures, open chromatin, multiple nucleoli
Sarcoma
Tumor type?
Benign or malignant?
mesenchymal- lipoma
benign
An owner reports that she thinks a previously diagnosed lipoma has become cancerous and spread to the other areas of the dog’s ventrum. Is this a possibility?
No, liposarcomas do not arise from malignant transformations of lipomas
If you suspect that around an surgery scar there is an area of scar tissue/reactive fibroplasia, what should you do to confirm?
Histopathology
What is the most common cutaneous tumor of horses?
sarcoid
A firm, SQ mass is palpated on the hind end of a horse. On cytology of the mass, it appears mesenchymal. What are the top three differentials? How would you confirm?
sarcoid
Granulation tissue
fibroma
Perform histopathology to confirm tumor and biologic behavior
What four ST sarcomas do we typically all treat the same?
perivascular wall tumor
fibrosarcoma
myxosarcoma
peripheral nerve sheath tumor
Describe the characteristics of perivascular wall tumors.
High exfoliation
very vascular
multinucleated cells with peripheral nuclei (crown cells)***
very wispy cytoplasm and anaplastic cells
small punctate vacuoles
1-2 nucleoli
Tumor type?
mesenchymal, perivascular wall tumor
Tumor type
Soft tissue sarcoma
Tumor type?
ST sarcoma