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Cytodiagnostics > Hepatobiliary cytology > Flashcards

Hepatobiliary cytology Flashcards

1
Q

Which liver diseases are more accurately diagnosed with a wedge biopsy than tru-cut (aka need more tissue)?

A

hepatitis/cirrhosis

fibrosis

cholangitis

portovascular anomaly

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2
Q

What value is important to check prior to aspiration of liver?

A

PLT

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3
Q

For which type of liver diseases is FNA of the liver good?

A

Diffuse diseases

hepatic lipidosis, vacuolar hepatopathy, lymphoma, neutrophilic hepatitis

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4
Q

For which type of liver diseases is an FNA not good?

A

Focal diseases

lymphocytic inflammation, fibrosis, cirrhosis, portovascular anomalies, focal mass, early mets

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5
Q

Based on the diagram shown, why is it that FNA can be a good screening tool but cannot for sure tell that a lesion is neoplastic vs. hyperplastic?

A

could sample hyperplastic area but not neoplastic region

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6
Q

What cells are shown in the picture?

Are the black granules normal?

A

Liver cells (hepatoid in shape, coarse chromatin, single nucleoli)

granules are normal

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7
Q

Normal or abnormal?

A

normal nuclear crystals can be seen

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8
Q

Liver cells or biliary epithelium?

A

biliary epithelium

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9
Q

Are low #’s of mast cells normal to see in the liver?

A

YES

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10
Q

Type of vacuolization?

Level of severity?

DX?

A

distinct (accumulation of fat)

severe

hepatic lipidosis

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11
Q

This cytology is observed in the liver of a dog. What are the two most common causes?

A

pancreatitis & diabetes

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12
Q

Classify this liver aspirate.

What is accumulating?

In which species is this more common?

A

Indistinct vacuolization

glycogen or water accumulation

dogs

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13
Q

Describe the type of vacuolization in this liver cytology.

The degree of severity?

Name the two common causes of this?

A

Indistinct vacuolization

severe

(glycogen accumulates out of cell and squishes with nuclei and cytoplasm- makes middle dark)

steroid use or Cushing’s

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14
Q

What condition often results from severe vacuolization?

A

cholestasis from blockage of the bile canniculi

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15
Q

What is the pigment accumulating in the liver cells?

Cause?

A

Bile (cholestasis) or lipofuscin (wear and tear pigment, normal with age)

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16
Q

What change in the liver can be observed before there are changes in liver enzymes?

What does it indicate?

A

Bile casts (in black)

indicates cholestasis

17
Q

why is it difficult to determine cholangitis from hepatitis with cytology?

A

Tissue architecture not preserved

18
Q

What type of inflammation can be reliably detected with liver cytology?

A

neutrophilic inflammation

19
Q

In felines, what is the major difference between lymphocytic inflammation and lymphoma?

A

lymphoma often diffuse with a large liver

lymph inflammation often periportal and low #

20
Q

Can lymphoma be dx on cytology of the liver in a feline?

A

No, need tissue architecture

21
Q

What conditions could possibly result in a false + inflammation dx in the liver cytology?

A

leukocytosis

extramedullary hematopoiesis

Leukemia

abdominal effusion

22
Q

Classify this liver cytology.

A

hyperplasia

(Increase in binucleation, anisokaryosis, pleomorphism
Hard to ddx from neoplasia***)

23
Q

What are the characteristics associated with nodular hyperplasia compared to regenerative nodules in the liver?

A

nodular hyperplasia: vacuoles, pigment, EMH (idiopathic, older dogs, incr. ALP, no C.S.)

regenerative: bile pigment in vacoules, bile casts evidence of cholestasis,

24
Q

Metastatic neoplasia is more common in the liver than primary neoplasia. T/F?

A

TRUE

25
Q

Which is more common in dogs vs. cats— hepatocellular or biliary neoplasia?

A

dogs: hepatocellular
cats: biliary

26
Q

What is the most commonly dx liver neoplasm?

A

lymphoma

27
Q

Is hepatocellular carcinoma more commonly diffuse in the liver or focal mass?

A

DIFFUSE

28
Q

Classify this liver cytology.

A

Neoplastic, anaplastic carcinoma

29
Q

Classify this liver cytology.

A

Bile duct carcinoma

30
Q

Classify this liver cytology.

A

Lymphoma

Cytodiagnostics (9 decks)

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